Skip to main content
SpringerLink
Log in
Book cover

Trace Elements in Man and Animals 10 pp 429–432Cite as

Zinc-Induced Excessive Glutamate Release may Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse

  • Chapter
  • First Online:

  • 26 Accesses

Conclusion

Our results demonstrated that an abnormal glutamate neurotransmission caused by Zn deficiency induces neuronal cell injury in the hippocampus of SAMP 10. These neuronal disturbances may cause accelerated aging of brain of SAMP 10 with deficits in learning and memory (Fig. 2).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Assaf, S.Y. and Chung, S.-H., 1984, Release of endogenous Zn2+ from rat brain tissue during activity, Nature 308:734–736.

    Article  CAS  Google Scholar 

  • Guidolin, D., Polato, P., Venturin, G., Zanotti, A., Mocchegiani, E., Fabris, N., and Nunzi, M.G., 1992, Correlation between zinc level in hippocampal mossy fibers and Spatial memory in aged rats, Ann. N Y Acad. Sci. 673:187–193.

    Article  CAS  Google Scholar 

  • Itoh, T., Saito, T., Fujimura, M., Watanabe, S., and Saito, K., 1993, Restraint stress-induced changes in endogenous zinc release from the rat hippocampus, Brain Res. 618:318–322.

    Article  CAS  Google Scholar 

  • Saito, K., Watanabe, S., Itoh, T., and Saito, T., 1994, Dynamics of trace and ultra-trace elements in the brain, Hokkaido Univ. Med. Lib. 31:11–17.

    Google Scholar 

  • Takeda, T., Hosokawa, M., Takeshita, S., Irio, K., Higuchi, T., Matsushita, T., Tomita, Y., Yasuhira, K., Hashimoto, H., Shimizu, K., Ishii, M., and Yamamura, T., 1981, A new murine model of accelerated senescence, Mech. Aging Dev. 17:183–194.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Environmental Biology Department of Preventive Medicine, Hokkaido University School of Medicine, Sapporo, Japan

    Takeshi Saito, Noriko Nakagawa, Kyoko Takahashi, Dan Li, Yuwako Yamamoto, Hiroko Sasaki, Nozomu Nakamura, Kazuhiro Ogawa & Hiroyoshi Fujita

  2. Department of Environmental Medicine and Informatics Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan

    Masaaki Kurasaki & Masashi Okabe

  3. Center for Research and Development in Higher Education, Hokkaido University, Sapporo, Japan

    Toshiyuki Hosokawa

Authors
  1. Takeshi Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noriko Nakagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyoko Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuwako Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroko Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nozomu Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kazuhiro Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroyoshi Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masaaki Kurasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Masashi Okabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Toshiyuki Hosokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Joseph Fourier University, Grenoble, France

    A. M. Roussel  & A. E. Favier  & 

  2. Beltsville Human Nutrition Research Center, Beltsville, Maryland, USA

    R. A. Anderson

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Saito, T. et al. (2002). Zinc-Induced Excessive Glutamate Release may Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_133

Download citation

  • DOI: https://doi.org/10.1007/0-306-47466-2_133

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-46378-5

  • Online ISBN: 978-0-306-47466-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation