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C. elegans

Methods and Applications

  • Kevin Strange

Part of the Methods in Molecular Biology book series (MIMB, volume 351)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Kevin Strange
    Pages 1-11
  3. Avril Coghlan, Jason E. Stajich, Todd W. Harris
    Pages 13-29
  4. Todd W. Harris, Lincoln D. Stein
    Pages 31-50
  5. Robert J. Barstead, Donald G. Moerman
    Pages 51-58
  6. M. Wayne Davis, Marc Hammarlund
    Pages 75-92
  7. Todd Lamitina
    Pages 127-138
  8. Larry J. Bischof, Danielle L. Huffman, Raffi V. Aroian
    Pages 139-154
  9. Harald Hutter
    Pages 155-173
  10. Michael M. Francis, Andres Villu Maricq
    Pages 175-192
  11. Christopher J. Cronin, Zhaoyang Feng, William R. Schafer
    Pages 241-251
  12. Rex A. Kerr, William R. Schafer
    Pages 253-264
  13. Kevin Strange, Rebecca Morrison
    Pages 265-273
  14. Back Matter
    Pages 287-292

About this book

Introduction

Molecular biology has driven a powerful reductionist, or “molecule-c- tric,” approach to biological research in the last half of the 20th century. Red- tionism is the attempt to explain complex phenomena by defining the functional properties of the individual components of the system. Bloom (1) has referred to the post-genome sequencing era as the end of “naïve reductionism. ” Red- tionist methods will continue to be an essential element of all biological research efforts, but “naïve reductionism,” the belief that reductionism alone can lead to a complete understanding of living organisms, is not tenable. Organisms are clearly much more than the sum of their parts, and the behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. Systems biology has emerged in the wake of genome sequencing as the s- cessor to reductionism (2–5). The “systems” of systems biology are defined over a wide span of complexity ranging from two macromolecules that interact to carry out a specific task to whole organisms. Systems biology is integrative and seeks to understand and predict the behavior or “emergent” properties of complex, multicomponent biological processes. A systems-level characteri- tion of a biological process addresses the following three main questions: (1) What are the parts of the system (i. e.

Keywords

SNP microscopy molecular biology mutant transcription

Editors and affiliations

  • Kevin Strange
    • 1
    • 2
    • 3
  1. 1.Department of AnesthesiologyVanderbilt University Medical CenterNashville
  2. 2.Department of Molecular Physiology and BiophysicsVanderbilt University Medical CenterNashville
  3. 3.Department of PharmacologyVanderbilt University Medical CenterNashville

Bibliographic information

  • DOI https://doi.org/10.1385/1597451517
  • Copyright Information Humana Press 2006
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-597-2
  • Online ISBN 978-1-59745-151-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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