Immunotherapy of Cancer

1. Interleukin-2 as Cancer Therapy

   • Joseph I. Clark, Kim A. Margolin

   Pages 355-364

2. Biological and Clinical Properties of the Type 1 Interferons

   • Douglas W. Leaman, Shaun Rosebeck, Ernest C. Borden

   Pages 365-396

3. Promising γ-Chain Cytokines for Cancer Immunotherapy

   • Terry J. Fry, Crystal L. Mackall

   Pages 397-414

4. The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies

   • Sherif S. Farag, Michael A. Caligiuri

   Pages 415-432

5. Antibody Therapy for Solid Tumors

   • Cristina I. Truica, Dorinda Rouch, Carlos L. Arteaga

   Pages 433-444

6. Antibody Therapy for Non-Hodgkin’s Lymphoma

   • Stephen M. Ansell, Thomas E. Witzig

   Pages 445-455

7. Approaches to In Vivo Imaging of Cancer Immunotherapy

   • George A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, Keith L. Knutson

   Pages 457-477

8. Design Issues for Early-Stage Clinical Trials for Cancer Vaccines

   • Gina R. Petroni

   Pages 479-485

9. Monoclonal Antibody Therapy of Cancer

   • Hossein Borghaei, Matthew K. Robinson, Louis M. Weiner

   Pages 487-502

10. Back Matter

    Pages 503-516

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Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

• Antigen
• T cell
• cell
• cell therapy
• clinical trial
• cytokine
• cytokines
• imaging
• imaging techniques
• immunotherapy
• innate immunity
• interferon
• lymphoma
• tumor
• vaccine

From the reviews:

"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. … The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers … ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)

• University of Washington School of Medicine, Seattle

  Mary L. Disis

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