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Combination Cancer Therapy

Modulators and Potentiators

  • Book
  • © 2005

Overview

Editors:
  1. Gary K. Schwartz

    1. Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Targeting of the EGFR As a Modulator of Cancer Chemotherapy

    • Jose Baselga
    Pages 1-26

  3. Cyclin-Dependent Kinase Inhibitors in Combination Chemotherapy

    • Manish A. Shah, Gary K. Schwartz
    Pages 27-60

  4. Development of Protein Kinase C and Cyclin-Dependent Kinase Inhibitors As Potentiators of Cytotoxic Drug Action in Leukemia

    • Steven Grant
    Pages 61-87

  5. Carboxyamidotriazole, an Inhibitor of Nonvoltage-Operated Calcium Entry

    • Chad M. Michener, Elise C. Kohn
    Pages 89-105

  6. Targeted α-Particle Therapy

    • John M. Burke, David A. Scheinberg, Joseph G. Jurcic
    Pages 107-131

  7. Pharmacological Modulation of Fluoropyrimidines

    • Owen A. O’Connor
    Pages 133-174

  8. Development of Inhibitors of HER2 With Taxanes

    • Shanu Modi, Monica N. Fornier, Andrew D. Seidman
    Pages 175-195

  9. Targeting NF-κB to Increase the Activity of Cisplatin in Solid Tumors

    • Don S. Dizon, Carol Aghajanian, X. Jun Yan, David R. Spriggs
    Pages 197-207

  10. Combinations of Chemotherapy and G3139, an Antisense Bcl-2 Oligonucleotide

    • Luba Benimetskaya, Sridhar Mani, C. A. Stein
    Pages 209-230

  11. Use of Animal Models to Evaluate Signal Transduction Inhibitors As Modulators of Cytotoxic Therapy

    • Beverly A. Teicher
    Pages 231-275

  12. Back Matter

    Pages 277-284
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Keywords

About this book

Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatments in cancer therapy.

Reviews

"It offers everyone in the field of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects of cancer patients." - Neoplasma

Editors and Affiliations

  • Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York

    Gary K. Schwartz

Bibliographic Information

  • Book Title: Combination Cancer Therapy

  • Book Subtitle: Modulators and Potentiators

  • Editors: Gary K. Schwartz

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1385/1592598641

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-200-1Published: 03 December 2004

  • Softcover ISBN: 978-1-62703-806-5Published: 25 November 2014

  • eBook ISBN: 978-1-59259-864-9Published: 27 October 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 284

  • Topics: Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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