Adoptive Immunotherapy

1. Regulatory T-Cells in Antitumor Therapy Isolation and Functional Testing of CD4+CD25+Regulatory T-Cells

   • Helmut Jonuleit, Edgar Schmitt

   Pages 285-296

2. Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation

   • Lucienne Chatenoud

   Pages 297-328

3. Producing Bispecific and Bifunctional Antibodies

   • Dipankar Das, Mavanur R. Suresh

   Pages 329-345

4. Antibody-Cytokine Fusion Proteins for the Therapy of Cancer

   • Gustavo Helguera, Manuel L. Penichet

   Pages 347-373

5. Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate

   • Ahmad Safavy, Kevin P.

   Pages 375-388

6. Cytotoxic Tumor Targeting With scFv Antibody-Modified Liposomes

   • Cornelia Marty, Reto A. Schwendener

   Pages 389-401

7. Intravenous Immunoglobulin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions

   • I lan Krause, Yehuda Shoenfeld

   Pages 403-408

8. Study of T-Cell Costimulatory Blockade In Vivo at a Single-Cell Level

   • Minh Diem Vu, Xian Chang Li

   Pages 409-420

9. Stem Cell Transplantation: Graft-Mediated Antileukemia Effects

   • William J. Hogan, Hans Joachim Deeg

   Pages 421-444

10. Influence of Radiation Protocols on Graft-vs-Host Disease Incidence After Bone-Marrow Transplantation in Experimental Models

    • Sebastian Schwarte, Matthias W. Hoffmann

    Pages 445-458

11. Induction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated Mice

    • Nikos Emmanouilidis, Christian P. Larsen

    Pages 459-468

12. Induction of Mixed vs Full Chimerism to Potentiate GVL Effects After Bone-Marrow Transplantation

    • Markus Y. Mapara, Megan Sykes

    Pages 469-474

13. Application of Donor Lymphocytes Expressing a Suicide Gene for Early GVL Induction and Later Control of GVH Reactions After Bone-Marrow Transplantation

    • Attilio Bondanza, Fabio Ciceri, Chiara Bonini

    Pages 475-486

14. Back Matter

    Pages 487-500

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An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.

• Antigen
• autoimmunity
• cancer
• clinical trial
• cytokine
• immunotherapy
• infection
• leukemia
• proteins
• stem cell transplantation
• transplantation
• tumor

"...a comprehensive and authoritative collection of currently used protocols for adoptive immunotherapy in both pre-clinical and clinical settings." - Immunology News

"...will be not only useful for basic researchers but also clinical scientists aiming to translate basic research to a clinical setting." - Immunology and Cell Biology

• Research Department, Kantonsspital St. Gallen, Switzerland

  Burkhard Ludewig

• Department of Abdominal and Transplant Surgery, Hannover Medical School, Hannover, Germany

  Matthias W. Hoffmann

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