Adoptive Immunotherapy: Methods and Protocols

  • Burkhard Ludewig
  • Matthias W. Hoffmann

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 109)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Gennady Bocharov, Neville J. Ford, Burkhard Ludewig
    Pages 19-33
  3. Ying Waeckerle-Men, Bruno Gander, Marcus Groettrup
    Pages 35-46
  4. Frank Grünebach, Martin R. Müller, Peter Brossart
    Pages 47-54
  5. John D. M. Campbell, Christoph Piechaczek, Gregor Winkels, Edith Schwamborn, Daniela Micheli, Sonja Hennemann et al.
    Pages 55-70
  6. Thomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nussbaumer et al.
    Pages 71-81
  7. Rienk Offringa, Kitty Kwappenberg, Martijn Rabelink, Delphine Rea, Rob Hoeben
    Pages 83-95
  8. I. Jolanda, M. de Vries, Gosse J. Adema, Cornelis J. A. Punt, Carl G. Figdor
    Pages 113-125
  9. Volker L, Reichardt and Peter Brossart
    Pages 127-135
  10. Özlem Türeci, Dirk Usener, Sandra Schneider, Ugur Sahin
    Pages 137-154
  11. Petra Weingarten, Petra Lutter, Andreas Wattenberg, Martin Blueggel, Sonja Bailey, Joachim Klose et al.
    Pages 155-173
  12. Helga Bernhard, Burkhard Schmidt, Dirk H. Busch, Christian Peschel
    Pages 175-184
  13. Helmut W. H. G. Kessels, Monika C. Wolkers, Ton N. M. Schumacher
    Pages 201-213
  14. Liquan Gao, Anne-Marie Downs, Hans J.
    Pages 215-228
  15. Ralf-Holger Voss, Jürgen Kuball, Matthias Theobald
    Pages 229-256

About this book

Introduction

Over the last decade, major advances in our understanding of the immune system and its mechanisms have led to promising new treatment strategies. In Adoptive Immunotherapy: Methods and Protocols, leading experts describe in detail their optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T-cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immonotherapy, and the utilization of regulatory T-cells. Theoretical overviews and discussion of future directions for the improvement of adoptive immunotherapy complete the volume. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and state-of-the-art, Adoptive Immunotherapy: Methods and Protocols offers an authoritative collection of novel techniques to study the adoptive transfer of tailored antigen-specific immune cells and to improve their clinical application.

Keywords

Antigen autoimmunity cancer clinical trial cytokine immunotherapy infection leukemia proteins stem cell transplantation transplantation tumor

Editors and affiliations

  • Burkhard Ludewig
    • 1
  • Matthias W. Hoffmann
    • 2
  1. 1.Research DepartmentKantonsspital St. GallenSwitzerland
  2. 2.Department of Abdominal and Transplant SurgeryHannover Medical SchoolHannoverGermany

Bibliographic information

  • DOI https://doi.org/10.1385/1592598625
  • Copyright Information Humana Press 2005
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-406-7
  • Online ISBN 978-1-59259-862-5
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • About this book
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