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Antisense Therapeutics

  • Book
  • © 2005

Overview

Editors:
  1. M. Ian Phillips

    1. Vice President for Research, University of South Florida, Tampa

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Medicine (MIMM, volume 106)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Antisense Therapeutics

      • M. Ian Phillips
      Pages 3-10

    3. Antisense Inhibition

      • Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, M. Ian Phillips
      Pages 11-34

  3. Cardiovascular

    1. Front Matter

      Pages 35-35
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    2. Local Application of Antisense for Prevention of Restenosis

      • Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, Martin B. Leon
      Pages 37-50

    3. Antisense Therapeutics for Hypertension

      • M. Ian Phillips, Birgitta Kimura
      Pages 51-67

    4. Antisense Strategies for the Treatment of Heart Failure

      • Sian E. Harding, Federica del Monte, Roger J. Hajjar
      Pages 69-82

  4. Cancer

    1. Front Matter

      Pages 83-83
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    2. Clinical Studies of Antisense Oligonucleotides for Cancer Therapy

      • Rosanne M. Orr, F. Andrew Dorr
      Pages 85-111

    3. Antisense Therapy in Clinical Oncology

      • Ingo Tamm
      Pages 113-134

    4. Radionuclide-Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancer

      • Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao et al.
      Pages 135-191

    5. uppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors

      • Kazunori Aoki, Shumpei Ohnami, Teruhiko Yoshida
      Pages 193-204

    6. Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies

      • Manuel Rieber, Mary Strasberg-Rieber
      Pages 205-214

    7. Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance

      • Tadao Funato
      Pages 215-233

  5. Blood—Brain Barrier

    1. Front Matter

      Pages 235-235
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    2. Transport of Antisense Across the Blood-Brain Barrier

      • Laura B. Jaeger, William A. Banks
      Pages 237-251

  6. Dermal

    1. Front Matter

      Pages 253-253
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    2. Transdermal Delivery of Antisense Oligonucletoides

      • Rhonda M. Brand, Patrick L. Iversen
      Pages 255-269

  7. Drugs

    1. Front Matter

      Pages 271-271
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Keywords

About this book

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.

Reviews

From Reviews of the First Edition...

"...strongly recommended both to scientists already engaged in antisense research and to newcomers alike." -Trends in Biotechnology

"...enables an appreciation of the exciting possibilities this field offers for the development of new uniquely selective therapeutic agents via precisely designed inhibitors of the expression of disease associated genes." -Journal of Medicinal Chemistry

Reviews from the Second Edition...

"This book does an excellent job of showing the reader that antisense oligonucletoids could be valuable therapeutic drugs in the future." - Doody's Health Sciences Book

Editors and Affiliations

  • Vice President for Research, University of South Florida, Tampa

    M. Ian Phillips

Bibliographic Information

  • Book Title: Antisense Therapeutics

  • Editors: M. Ian Phillips

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/1592598544

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-205-6Published: 16 September 2004

  • Softcover ISBN: 978-1-61737-421-0Published: 10 November 2010

  • eBook ISBN: 978-1-59259-854-0Published: 01 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 2

  • Number of Pages: 344

  • Number of Illustrations: 56 b/w illustrations

  • Topics: Cell Biology

  • Industry Sectors: Biotechnology, Pharma

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