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Drug Metabolism and Transport

Molecular Methods and Mechanisms

  • Lawrence H. Las

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Hollie I. Swanson, Susan D. Kraner, Soma S. Ray, Martin Hoagland, Earl D. Thompson, Xinyu Zheng et al.
    Pages 19-44
  3. Sang K. Kim, Kimberley J. Woodcroft, Raymond F. Novak
    Pages 45-83
  4. Philip G. Board, M. W. Anders, Anneke C. Blackburn
    Pages 85-107
  5. Anna Radominska-Pandya, Joanna M. Little, Arthur Bull
    Pages 109-132
  6. Anna Radominska-Pandya, Peter I. Mackenzie, Wen Xie
    Pages 133-171
  7. Craig K. Svensson, David W. Hein
    Pages 173-195
  8. Bernhard H. Lauterburg
    Pages 233-251
  9. Lawrence H. Lash
    Pages 319-339
  10. Charles N. Falany
    Pages 341-378
  11. Back Matter
    Pages 379-387

About this book

Introduction

Remarkable advances in molecular and cell biology and the development of novel in vitro model systems have greatly expanded our knowledge of the processes involved in metabolism and transport and led to numerous new therapeutic approaches. In Drug Metabolism and Transport: Molecular Methods and Mechanisms, well-established investigators describe their best experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems. Many chapters contain step-by-step methods for investigating metabolism and transport.
Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.

Keywords

cytochrome P450 detoxification drug drug resistance metabolism research resistance toxicity toxicology xenobiotic xenobiotics

Editors and affiliations

  • Lawrence H. Las
    • 1
  1. 1.Department of PharmacologyWayne State University School of MedicineDetroit

Bibliographic information

  • DOI https://doi.org/10.1385/1592598323
  • Copyright Information Humana Press 2005
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-324-4
  • Online ISBN 978-1-59259-832-8
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site
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