Membrane Microdomain Signaling

Lipid Rafts in Biology and Medicine

  • Mark P. Mattson

Table of contents

  1. Front Matter
    Pages i-x
  2. Ephraim Yavin, Annette Brand
    Pages 1-14
  3. Elizabeth J. Luna, Thomas Nebl, Norio Takizawa, Jessica L. Crowley
    Pages 47-69
  4. Christopher J. Fielding
    Pages 71-89
  5. Arnold H. van der Luit, Marcel Verheij, Wim J. van Blitterswijk
    Pages 91-112
  6. Wu Ou, Jonathan Silver
    Pages 127-142
  7. Mark P. Mattson, Roy G. Cutler, Norman J. Haughey
    Pages 143-160
  8. Mordechai Liscovitch, Elke Burgermeister, Neeru Jain, Dana Ravid, Maria Shatz, Lilach Tencer
    Pages 161-190
  9. Mark P. Mattson
    Pages 191-201
  10. Back Matter
    Pages 203-214

About this book


Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.


aging apoptosis biology cancer membrane metabolism nervous system protein regulation signal transduction skeleton virus

Editors and affiliations

  • Mark P. Mattson
    • 1
    • 2
  1. 1.Laboratory of Neurosciences, Intramural Research ProgramNational Institute on AgingBaltimore
  2. 2.Department of NeuroscienceJohns Hopkins University School of MedicineBaltimore

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