Lung Cancer

1. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and Prognosis

   1. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical Samples

      1. Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT

         • Veerle A. M. C. Somers, Frederick B. J. M. Thunnissen

         Pages 305-323

      2. Detection of K-ras and p53 Mutations by “Mutant-Enriched” PCR-RFLP

         • Marcus Schuermann

         Pages 325-333

      3. Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor

         • Judy M. Coulson, Samreen I. Ahmed, John P. Quinn, Penella J. Woll

         Pages 335-352

      4. Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors

         • Nelson G. Ordóñez

         Pages 355-368

      5. Molecular Biologic Substaging of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded Tissue

         • Mary-Beth Moore Joshi, Thomas A. D’Amico, David H. Harpole Jr.

         Pages 369-388

      6. A Sensitive Immunofluorescence Assay for Detection of p53 Protein in the Sputum

         • Zumei Feng, Defa Tian, Radoslav Goldman

         Pages 389-395

      7. SPR1

         • Derick Lau, Linlang Guo, Andrew Chan, Reen Wu

         Pages 397-403

      8. Determination of Biological Parameters on Fine-Needle Aspirates from Non-Small Cell Lung Cancer

         • Cecilia Bozzetti, Annamaria Guazzi, Rita Nizzoli, Nadia Naldi, Vittorio Franciosi, Stefano Cascinu

         Pages 405-420

      9. Detection and Analysis of Lung Cancer Cells from Body Fluids Using a Rare Event Imaging System

         • Stine-Kathrein Kraeft, Ravi Salgia, Lan Bo Chen

         Pages 423-430

      10. Reconstruction of Geno-Phenotypic Evolutionary Sequences from Intracellular Patterns of Molecular Abnormalities in Human Solid Tumors

          • Stanley E. Shackney, Charles A. Smith, Agnese A. Pollice, Jan F. Silverman

          Pages 431-449

2. Novel Therapies

   1. Front Matter

      Pages 451-451

      PDF

   2. Introduction to Current Treatments

      1. Surgical Treatment of Lung Cancer

         • Clifton F. Mountain, Kay E. Hermes

         Pages 453-487

      2. Recent Advances and Dilemmas in the Radiotherapeutic Management of Locally Advanced Non-Small Cell Lung Cancer

         • Benjamin Movsas

         Pages 489-505

      3. Photodynamic Therapy in Lung Cancer

         • David Ost

         Pages 507-526

   3. Gene Therapies

      1. Gene Therapy for Lung Cancer

         • Eric B. Haura, Eduard Sotomayor, Scott J. Antonia

         Pages 529-543

      2. Identifying Obstacles to Viral Gene Therapy for Lung Cancer

         • Raj K. Batra, Raymond M. Bernal, Sherven Sharma

         Pages 545-559

      3. Topical Gene Therapy for Pulmonary Diseases with PEI-DNA Aerosol Complexes

         • Ajay Gautam, J. Clifford Waldrep, Frank M. Orson, Berma M. Kinsey, Bo Xu, Charles L. Densmore

         Pages 561-572

      4. Targeted Delivery of Expression Plasmids to the Lung via Macroaggregated Polyethylenimine-Albumin Conjugates

         • Frank M. Orson, Berma M. Kinsey, Balbir S. Bhogal, Ling Song, Charles L. Densmore, Michael A. Barry

         Pages 575-590

      5. Preparation of Retroviral Vectors for Cell-Cycle-Targeted Gene Therapy of Lung Cancer

         • Pier Paolo Claudio, Antonio Giordano

         Pages 591-605

      6. Aerosol Gene Therapy for Metastatic Lung Cancer Using PEI-p53 Complexes

         • Ajay Gautam, J. Clifford Waldrep, Eugenie S. Kleinerman, Bo Xu, Yuen-Kai Fung, Anne T’Ang et al.

         Pages 607-618

This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer—both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.

"This is a good compilation of scientific information on lung cancer...it serves as a useful resource for scientists involved in lung cancer." -Doody's Health Sciences Book Review Journal

"The strongest part of the book is the detailed description of the different molecular techniques for marker analyses, which will be of great value for the lung cancer scientists working in basic science ant translational lung cancer research." -Annals of Oncology

• Children#x2019;s Hospital, Los Angeles

  Barbara Driscoll

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