Molecular Analysis of Cancer

  • Jacqueline Boultwood
  • Carrie Fidler

Part of the Methods in Molecular Medicine book series (MIMM, volume 68)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ken Mills
    Pages 1-5
  3. Eva Hilgenfeld, Cristina Montagna, Hesed Padilla-Nash, Linda Stapleton, Kerstin Heselmeyer-Haddad, Thomas Ried
    Pages 29-44
  4. Binaifer R. Balsara, Jianming Pei, Joseph R. Testa
    Pages 45-57
  5. Rachel E. Ibbotson, Martin M. Corcoran
    Pages 59-65
  6. Yunfang Jiang, L. Jeffrey Medeiros, Andreas H. Sarris
    Pages 97-105
  7. Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Arthur B. McKie, Nicholas R. Lemoine
    Pages 107-114
  8. Per Guldberg, Kirsten Grønbœk, Jesper Worm, Per thor Straten, Jesper Zeuthen
    Pages 125-139
  9. Amanda Strickson, Carrie Fidler
    Pages 171-177
  10. Chuang Fong Kong, David Bowtell
    Pages 195-204
  11. Javed Khan, Lao H. Saal, Michael L. Bittner, Yuan Jiang, Gerald C. Gooden, Arthur A. Glatfelter et al.
    Pages 205-222
  12. Haruo Sugiyama
    Pages 223-237
  13. John T. Phelan II, Josef T. Prchal
    Pages 251-270

About this book

Introduction

Molecular biotechnology has in recent years produced significant advances in finding tumor markers useful in diagnosis and in the assessment of disease progression and prognosis. In Molecular Analysis of Cancer, leading researchers in the field describe in step-by-step detail their best state-of-the-art molecular techniques for elucidating the biochemical processes associated with human cancer. Among the techniques presented for identifying chromosomal rearrangements are fluorescent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), microsatellite analysis, PCR and RT-PCR, and DNA fingerprinting. Additional methods include SSCP, DGGE, the nonisotopic RNase cleavage assay, and the protein truncation assay and DNA sequencing for identifying mutations. Techniques for the analysis of gene expression include microarray technology and differential display. All these techniques are of great value for identifying genes that are central to cancer development and progression.
Comprehensive and state-of-the-art, Molecular Analysis of Cancer not only offers today's researcher a deeper understanding of cancer's molecular pathogenesis, but also provides a detailed examination of each of the major methodologies needed to detect and analyze its associated genetic abnormalities.

Editors and affiliations

  • Jacqueline Boultwood
    • 1
  • Carrie Fidler
    • 1
  1. 1.Leukaemia Research Fund Molecular Haematology UnitUniversity of Oxford, NDCLS, John Radcliffe HospitalOxfordUK

Bibliographic information

  • DOI https://doi.org/10.1385/1592591353
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-622-2
  • Online ISBN 978-1-59259-135-0
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • About this book
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