G Protein Methods and Protocols

1. Front Matter

   Pages i-xiv

   PDF

2. In Vitro Autoradiographic Localization of Receptor-Stimulated [35S]GTPγS Binding in Brain

   • Laura J. Sim, Dana E. Selley, Steven R. Childers

   Pages 1-27

3. Small-Molecular-Weight G Proteins

   • Rajinder Pal Bhullar

   Pages 29-51

4. G Proteins in the Etiology and Treatment of Mental Disorders

   • Jan O. Gordeladze, Per Wiik Johansen

   Pages 53-79

5. G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions

   • Zdenek B. Pristupa, Roger K. Sunahara, Hyman B. Niznik

   Pages 81-118

6. Modulation of G Proteins in Rat Striatum by Neuroleptic Drugs and a Peptidomimetic Analog of Pro-Leu-Gly-NH2

   • Willard J. Costain, Suresh K. Gupta, Rodney L. Johnson, Ram K. Mishra

   Pages 119-138

7. G Proteins and Animal Models of Parkinson’s Disease

   • Eric R. Marcotte, Ram K. Mishra

   Pages 139-161

8. Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling

   • Paul R. Albertau, Paola M. C. Lembo, Stephen J. Morris

   Pages 163-187

9. Molecular Mechanisms of Opiate Addiction in the Nucleus Accumbens

   • Katherine L Widnell, Eric J. Mestler

   Pages 189-205

10. G Protein-Linked Opioid Receptors

    • Pushkar Sharma, Ivone Gomes, Shail K. Sharma

    Pages 207-221

11. G Protein-Coupled melatonin receptors

    • Lennard P. Niles

    Pages 223-281

12. G Proteins in the Pathophysiology and Treatment of Mood and Anxiety Disorders

    • Husseini K. Mangi

    Pages 283-325

13. Determination of Adenosine Receptor-G Protein Coupling

    • Anna Lorenzen

    Pages 327-352

14. G Proteins and Mood Disorders

    • Jun-Feng Wang, L. Trevor Young

    Pages 353-377

15. G Proteins in the Medial Temporal Lobe in Schizophrenia

    • Fumihiko Okada

    Pages 379-391

16. G Protein Abnormalities in Schizophrenia

    • Naoki Nishino, Noboru Kitamura, Chang-Qing Yang, Hideo Yamamoto, Yutaka Shirai, Yasuo Kajimoto et al.

    Pages 393-418

17. Back Matter

    Pages 419-433

    PDF

03490-9, Hardcover, April 22, 1997,

G PROTEIN METHODS AND PROTOCOLS: Role of Proteins in Psychiatric and Neurological Disorders
Edited by
Ram K. Mishra, McMaster University, Hamilton, Ontario, Canada
Glen B. Baker, University of Alberta, Edmonton, Canada
Alan A. Boulton, University of Saskatoon, Canada

Combining the cutting-edge insights of leading basic and clinical investigators, G Protein Methods and Protocols provides both critical reviews and detailed protocols for studying the medical role played by G proteins and signal transduction in mental and neurological disease. The psychiatric and neurological disorders covered range from Parkinson's disease and schizophrenia to manic depression, drug addiction, and mood and anxiety disorders. The protocols contain the latest methods and techniques for G protein analysis and application in research related to the central nervous system.

This new work marks a novel departure from books focused narrowly on the physical properties of G proteins in isolation. By providing detailed methods and techniques, this volume's front-line contributors bring out the implications of G protein signal transduction for psychiatric and neurological disorders. Practical and authoritative, G Protein Methods and Protocols will surely prove a major practical resource for all neurochemists, neurologists, molecular biologists, pharmacologists, and psychiatrists seeking to study and better understand these disease states.

• McMaster University, Hamilton, Canada

  Ram K. Mishra

• University of Alberta, Edmonton, Canada

  Glen B. Baker

• University of Saskatchewan, Saskatoon, Canada

  Alan A. Boulton

Policies and ethics