Neural Development and Stem Cells

  • Mahendra S. Rao

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-x
  2. Daniel A. Lim, Arturo Alvarez-Buylla
    Pages 29-47
  3. Ali Jalali, Michael Bonaguidi, Caitilin Hamill, John A. Kessler
    Pages 67-95
  4. Rizwan S. Akhtar, Kevin A. Roth
    Pages 97-122
  5. Mark Noble, Margot Mayer-Pröschel
    Pages 143-188
  6. Houman D. Hemmati, Tanya A. Moreno, Marianne Bronner-Fraser
    Pages 189-217
  7. James E. Schwob, Woochan Jang
    Pages 219-233
  8. Ani V. Das, Jackson James, Sreekumaran Edakkot, Iqbal Ahmad
    Pages 235-247
  9. Ying Liu, Mahendra S. Rao
    Pages 249-265
  10. Steven A. Goldman
    Pages 267-297
  11. Robin L. Wesselschmidt, John W. McDonald
    Pages 299-341
  12. Jaime Imitola, Yang D. Teng, Vaclav Ourednik, Kook In Park, Richard L. Sidman, Evan Y. Snyder
    Pages 371-419
  13. Back Matter
    Pages 421-454

About this book


Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).


Nervous System behavior brain cell cell death development neural stem cells neurons stem cells

Editors and affiliations

  • Mahendra S. Rao
    • 1
  1. 1.National Institute on AgingBaltimore

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