The Oncogenomics Handbook

1. Cancer Target Validation: Animal Approaches

   1. Genetically Engineered Mouse Models of Human Cancer for Drug Discovery and Development

      • Rónán C. O’Hagan, Min Wu, William M. Rideout III, Yinghui Zhou, Joerg Heyer

      Pages 247-261

   2. Innovative Strategies for Improving Engineered Mouse Models of Human Cancer for Preclinical Development

      • Jeffrey J. Martino, Suzie Chen

      Pages 275-286

   3. Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes

      • Jeff L. Ellsworth, Andrew Feldhaus, Steven D. Hughes

      Pages 287-301

   4. Cancer Biology and Transgenic Technology in the Mouse

      • Cindy E. McKinney, Cooduvalli S. Shashikant

      Pages 303-321

   5. Homology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides

      • Gary C. Starling, William J. LaRochelle, Gulshan Ara

      Pages 323-335

2. Cancer Target Validation: Animal Approaches

   1. Unraveling the Complexity of Oncogenesis Through In Vivo Optical Imaging

      • Pamela Reilly Contag

      Pages 263-274

3. Cancer Prognostics, Diagnostics, and Biomarkers

   1. Front Matter

      Pages 337-337

      PDF

   2. Cancer Pharmacogenomics

      • Brian Z. Ring, Huijun Z. Ring

      Pages 339-357

   3. Diagnosis and Treatment of Malignancies Using Gene Expression Profiling

      • Jimmy C. Sung, Alice Y. Lee, Timothy J. Yeatman

      Pages 359-364

   4. Implications of Epigenetics for Early Cancer Diagnosis and Prevention

      • Mukesh Verma, Sudhir Srivastava

      Pages 365-375

   5. Novel Molecular and Genetic Prognostic Biomarkers in Prostate Cancer

      • Arnab Chakravarti, Gary Guotang Zhai

      Pages 377-391

   6. PSA in Prostate Cancer Diagnosis

      • Pradip Datta

      Pages 393-402

   7. Tumor Targets and Biomarkers in Renal Cell Carcinoma

      • Ivar Bleumer, Peter F. A. Mulders

      Pages 403-412

4. Emerging Approaches to Cancer Therapy

   1. Front Matter

      Pages 491-491

      PDF

   2. Targeting the Vasculature

      1. Tumor Vasculature as a Target for Cancer Therapy

         • Grzegorz Korpanty, Xianming Huang, Rolf A. Brekken

         Pages 415-428

      2. Targeting the VEGF/VEGFR Axis for Cancer Therapy

         • Frank A. Scappaticci

         Pages 429-440

      3. Inhibiting Cancer Angiogenesis With Molecular Therapy

         • Qixin Leng, A. James Mixson

         Pages 441-455

   3. Supportive and Adjuvant Therapies

      1. Development of Palifermin (rHuKGF) for Mucositis

         • Ping Wei, Catherine L. Farrell

         Pages 459-473

      2. Immune Modulations

         • Sheng Yao, Lieping Chen

         Pages 475-490

   4. Tumor-Targeted Therapies

      1. Proteasome Inhibition and Its Clinical Application in Solid Tumors

         • David J. Park, Heinz-Josef Lenz

         Pages 493-507

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

• apoptosis
• carcinoma
• classification
• diagnostics
• imaging
• senescence

"...an excellent resource to anyone interested in the field of cancer or cancer research. Its comprehensive overview of different perspectives in oncologic genomics will certainly be beneficial to a wide range of professionals in their ultimate endeavors towards further development of advanced cancer therapies." - Doody's Health Sciences and Book Review Journal

"...provides an integrated overview of cancer drug discovery and development...." - BioTech International

• CuraGen Corporation, New Haven

  William J. LaRochelle, Richard A. Shimkets

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