© 2005

Lower Extremity Arterial Disease

  • Dennis G. Caralis
  • George L. Bakris

Part of the Clinical Hypertension and Vascular Diseases book series (CHVD)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Dennis G. Caralis
    Pages 1-21
  3. Nicos Labropoulos, Apostolos K. Tassiopoulos
    Pages 23-38
  4. Albert J. Bellg, Aristdis N. Mavridis
    Pages 39-52
  5. George L. Bakris
    Pages 53-59
  6. Ambika Babu, C. R. Kannan, Theodore Mazzone
    Pages 61-73
  7. Anjula Gandhi, Jay Garg, George L. Bakris
    Pages 75-83
  8. Bassem Jamil Basha, George L. Bakris, James R. Sowers
    Pages 99-181
  9. Chad E. Jacobs, Walter J. McCarthy
    Pages 269-292
  10. Back Matter
    Pages 293-306

About this book


Although associated with coronary heart disease and generalized arteriosclerosis in a large number of patients, lower extremity arterial disease (LEAD) is a disease process by itself that only one in four patients will survive more than 10 years. Approximately 10 million men and women in the United States suffer from LEAD. In Lower Extremity Arterial Disease, leaders in the fields of cardiovascular medicine, hypertension, vascular surgery, vascular radiology, and vascular physiology join forces to comprehensively review the state-of-the-art concerning atherosclerosis of the arteries of the legs and feet. The authors discuss in detail LEAD's primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug-eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle-brachial index of every patient over 45.
Authoritative and up-to-date, Lower Extremity Arterial Disease offers family physicians, cardiologists, internists, radiologists, and cardiovascular surgeons a comprehensive analysis of all aspects of LEAD, ranging from diagnostic methodologies and pharmacotherapy to aggressive risk factor modification, transcatheter therapeutics, and gene therapy.


Diabetes Stent angiography arteries atherosclerosis coronary artery disease diagnosis differential diagnosis gene therapy heart hypertension management pain therapy vascular disease

Editors and affiliations

  • Dennis G. Caralis
    • 1
  • George L. Bakris
    • 2
  1. 1.Department of Medicine, Section of CardiologyRush University Medical CenterChicago
  2. 2.Department of Medicine, Division of NephrologyRush University Medical CenterChicago

Bibliographic information

  • Book Title Lower Extremity Arterial Disease
  • Editors Dennis G. Caralis
    George L. Bakris
  • Series Title Clinical Hypertension and Vascular Diseases
  • DOI
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-554-5
  • Softcover ISBN 978-1-61737-639-9
  • eBook ISBN 978-1-59259-881-6
  • Edition Number 1
  • Number of Pages XIII, 306
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Vascular Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Surgery & Anesthesiology


"...outstanding...provide(s) guidance for modern physicians on an ancient, but still poorly recognized, group of disorders." - Comprehensive Therapy