Vascular Dementia

Cerebrovascular Mechanisms and Clinical Management

  • Robert H. Paul
  • Ronald Cohen
  • Brian R. Ott
  • Stephen Salloway

Part of the Current Clinical Neurology book series (CCNEU)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Kelly L. Lange, Robert H. Paul
      Pages 3-5
    3. Gustavo C. Román
      Pages 7-21
    4. José G. Merino, Vladimir Hachinski
      Pages 57-71
  3. Basic Mechanisms of Vascular Dementia

    1. Front Matter
      Pages 73-73
    2. Jorge M. Serrador, William P. Milberg, Lewis A. Lipsitz
      Pages 75-86
    3. Sharon X. C. Yang, George A. Kuchel
      Pages 99-112
    4. Mark B. Moss, Elizabeth M. Jonak
      Pages 113-128
  4. The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living

    1. Front Matter
      Pages 129-129
    2. Angela L. Jefferson, Adam M. Brickman, Mark S. Aloia, Robert H. Paul
      Pages 131-143
    3. Sally Stephens, Raj Kalaria, Rose Anne Kenny, Clive Ballard
      Pages 145-156
    4. Anand Kumar, Helen Lavretsky, Ebrahim Haroon
      Pages 157-169
    5. Patricia A. Boyle, Deborah Cahn-Weiner
      Pages 171-177
  5. Neuroimaging of Vascular Dementia

    1. Front Matter
      Pages 179-179
    2. Ronald Cohen, Lawrence Sweet, David F. Tate, Marc Fisher
      Pages 181-209
    3. David J. Moser, Jason E. Kanz, Kelly D. Garrett
      Pages 223-229
    4. Anelyssa D′Abreu, Brian R. Ott
      Pages 231-241
  6. Interactions Between Vascular Dementia and Alzheimer’s Disease

    1. Front Matter
      Pages 243-243
    2. John Gunstad, Jeffrey Browndyke
      Pages 245-255
    3. Edward G. Stopa, Brian D. Zipser, John E. Donahue
      Pages 257-265
    4. Paula Grammas
      Pages 267-273
    5. Margaret M. Esiri, Zsuzsanna Nagy
      Pages 275-280
    6. David J. Libon, Stephen Scheinthal, Dana L. Penney, Rod Swenson
      Pages 281-293
  7. Clinical Management of Vascular Dementia

    1. Front Matter
      Pages 295-295
    2. Timo Erkinjuntti, Gustavo Román, Serge Gauthier, Kenneth Rockwood
      Pages 297-303
    3. Geoffrey Tremont, Jennifer Duncan Davis, Mary Beth Spitznagel
      Pages 305-321
    4. Rebecca E. Ready, Brian R. Ott
      Pages 323-329
  8. Back Matter
    Pages 341-356

About this book


With an aging population suffering from a high level of cardiac and cerebrovascular disease, it has become increasingly clear that the time may be ripe for a deeper understanding of vascular disease (VaD). In Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management, a panel of multidisciplinary experts summarizes our current understanding of the biological and clinical aspects of the condition. The authors describe the basic mechanisms associated with aging and cerebrovascular disease that may play an important role in the development of VaD, and identify its impact on cognitive status, psychiatric health, and the ability of patients to complete the tasks of daily living. Additional chapters address the pharmacological management of vascular dementia and the use of neuroimaging methods to investigate it, with particular attention devoted to both functional and structural imaging techniques. The complex relationship between VaD and Alzheimer's disease (AD) is fully explored, with chapters on how these processes may interact and how one disease may lower the threshold for clinical expression of the other. The authors also consider the impact of VaD on the perceived quality of life of patients and caregivers, two issues rarely discussed in the scientific community.
Comprehensive and thoroughly up-to-date, Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management offers both clinicians and basic scientists a wide ranging account of this rapidly developing field, explores the direction of future VaD studies, and authoritatively describes today's optimal therapeutic approaches.


Alzheimer alzheimer's disease brain brain imaging cognition dementia neuroprotection

Editors and affiliations

  • Robert H. Paul
    • 1
  • Ronald Cohen
    • 1
  • Brian R. Ott
    • 2
    • 3
  • Stephen Salloway
    • 3
    • 4
  1. 1.Department of Psychiatry and Human BehaviorBrown Medical SchoolProvidence
  2. 2.Department of NeurologyMemorial Hospital of Rhode IslandPawtucket
  3. 3.Department of Clinical NeurosciencesBrown Medical SchoolProvidence
  4. 4.Department of NeurologyButler HospitalUSA

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