Checkpoint Controls and Cancer

Volume 1: Reviews and Model Systems

  • Axel H. Schönthal

Part of the Methods in Molecular Biology™ book series (MIMB, volume 280)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Reviews of Checkpoint Controls, Their Involvement in the Development of Cancer, and Approaches to Their Investigation

    1. Front Matter
      Pages 1-1
    2. George R. Stark, William R. Taylor
      Pages 51-82
    3. P. Todd Stukenberg, Daniel J. Burke
      Pages 83-98
    4. Bipin C. Dash, Wafik S. El-Deiry
      Pages 99-161
  3. Analyzing Checkpoint Controls in Diverse Model Systems

    1. Front Matter
      Pages 163-163
    2. Sandra Pavey, Brian G. Gabrielli
      Pages 175-183
    3. Chu-Xia Deng, Xiaoling Xu
      Pages 185-200
    4. Vincenzo Costanzo, Kirsten Robertson, Jean Gautier
      Pages 213-227
    5. Burnley Jaklevic, Amanda Purdy, Tin Tin Su
      Pages 245-256
    6. Anton Gartner, Amy J. MacQueen, Anne M. Villeneuve
      Pages 257-274
    7. Christopher M. Yellman, Daniel J. Burke
      Pages 275-290
  4. Back Matter
    Pages 307-318

About this book


Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 1: Reviews and Model Systems, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers working at the cutting edges of their fields to comprehensively review the complexities of checkpoint controls and the model systems available to study them. The authors introduce all of the important components of checkpoint controls, describe their intricate interactions, and highlight the relevance of these processes to the cancer problem. Additional chapters illustrate the advantages of using such diverse model systems as intact human skin, knockout mice, Xenopus, and yeast, and show how they can cross-fertilize and accelerate research both across disciplines and beyond the boundaries of a particular species. A second volume, Activation and Regulation Protocols, provides readily reproducible experimental protocols for studying the molecular components of checkpoint controls and their regulation.
Comprehensive and up-to-date, the two volumes of Checkpoint Controls and Cancer offer novice and experienced researchers alike not only entré into the complexities of this vast field, but also to the full panoply of productive tools needed to deepen understanding of the systems, as well as to develop new and more effective cancer therapies.

Editors and affiliations

  • Axel H. Schönthal
    • 1
  1. 1.Department of Molecular Microbiology and Immunology and K. Norris Jr. Comprehensive Cancer CenterUniversity of Southern California Keck School of MedicineLos Angeles

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-214-8
  • Online ISBN 978-1-59259-788-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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