Protein Misfolding and Disease

Principles and Protocols

  • Peter Bross
  • Niels Gregersen

Part of the Methods in Molecular Biology™ book series (MIMB, volume 232)

Table of contents

  1. Front Matter
    Pages i-xv
  2. General Concepts and Models

    1. Front Matter
      Pages 1-1
    2. Niels Gregersen, Lars Bolund, Peter Bross
      Pages 3-16
    3. Peter Bross, Niels Gregersen
      Pages 17-26
    4. Marina S. Gelman, Ron R. Kopito
      Pages 27-37
    5. David H. Perlmutter
      Pages 39-56
    6. Lene Diness Jakobsen, Poul Henning Jensen
      Pages 57-66
    7. Melissa D. Scott, Judith Frydman
      Pages 67-76
    8. Christina M. Coughlan, Jeffrey L. Brodsky
      Pages 77-90
  3. General Methods

    1. Front Matter
      Pages 91-91
    2. Jane Nøhr, Karsten Kristiansen, Anne-M. Krogsdam
      Pages 93-101
    3. Anne-M. Krogsdam, Karsten Kristiansen, Jane Nøhr
      Pages 103-109
    4. Jane Nøhr, Karsten Kristiansen, Anne-M. Krogsdam
      Pages 111-125
    5. Jane Nøhr, Karsten Kristiansen
      Pages 127-131
  4. Techniques in Conformational Disease Research

    1. Front Matter
      Pages 147-147
    2. Ines Santisteban, Francisco X. Arredondo-Vega, Shannon Daniels, Michael S. Hershfield
      Pages 175-182
    3. Gopal Thinakaran, James W. Bowen, Daisuke Ito, Jae-Yoon Leem, Margaret L. Veselits, Naoyuki Sato
      Pages 203-216
    4. Annett Boeddrich, Rudi Lurz, Erich E. Wanker
      Pages 217-229
    5. Belén Pérez, Lourdes R. Desviat, Magdalena Ugarte
      Pages 245-256
    6. Lourdes R. Desviat, Belén Pérez, Magdalena Ugarte
      Pages 257-263
    7. Peter Bross, Vibeke Winter, Christina Bak Pedersen, Niels Gregersen
      Pages 285-293
  5. Back Matter
    Pages 313-318

About this book


It has now become clear that a large number of diseases with very different pathologies share a common framework of protein misfolding, accompanied by degradation and/or aggregation of the misfolded proteins. In Protein Misfolding and Disease: Principles and Protocols, notable experts in conformational disease review the latest thinking about the molecular processes underlying these diseases and describe cutting-edge biochemical, genomic, cellular, and chemical laboratory techniques for studying their genesis and pathologies. The authors apply their carefully refined methods to a variety of metabolic and neurodegenerative disorders, as well as to the aging process. The techniques presented are broadly applicable in many diverse disease contexts and may be used in both diagnosis and detailed research on new treatment strategies. Each tried and proven protocol includes insightful background notes, lists of required equipment and reagents, step-by-step instructions, and tips on troubleshooting and on how to avoid known pitfalls.
Comprehensive and cutting-edge, Protein Misfolding and Disease: Principles and Protocols offers both novice and experienced researchers a solid theoretical grounding in conformational disease and a remarkable set of analytical methodologies for uncovering its characteristics and generating new therapeutic approaches.

Editors and affiliations

  • Peter Bross
    • 1
  • Niels Gregersen
    • 1
  1. 1.Research Unit for Molecular MedicineSkejby SygehusAarhusDenmark

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-065-6
  • Online ISBN 978-1-59259-394-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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