Psychiatric Genetics

Methods and Reviews

  • Marion Leboyer
  • Frank Bellivier

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 77)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Wolfgang Maier
      Pages 3-20
  3. Methods in Psychiatric Genetics: Advantages and Limits

    1. Front Matter
      Pages 21-21
    2. Elena L. Grigorenko, David L. Pauls
      Pages 23-61
    3. Thomas Bourgeron, Bruno Giros
      Pages 63-98
    4. Philip Gorwood
      Pages 99-126
    5. Frank Bellivier
      Pages 127-141
  4. New Phenotypic Approaches

    1. Front Matter
      Pages 143-143
    2. Michael F. Egan, Terry E. Goldberg
      Pages 163-197
    3. Antonia S. New, Larry J. Siever
      Pages 199-213
    4. Robert Freedman
      Pages 215-225
  5. Conclusion

    1. Front Matter
      Pages 249-249
    2. Ming T. Tsuang, Levi Taylor, Stephen V. Faraone
      Pages 251-265
  6. Back Matter
    Pages 267-268

About this book


Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed.
Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved.

Editors and affiliations

  • Marion Leboyer
    • 1
  • Frank Bellivier
    • 2
  1. 1.Hôpital Albert ChenevierCreteilFrance
  2. 2.Hôpital Henri MondorCreteilFrance

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-037-3
  • Online ISBN 978-1-59259-348-4
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site
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