Tumor Suppressor Genes

Volume 2 Regulation, Function, and Medicinal Applications

  • Wafik S. El-Deiry

Part of the Methods in Molecular Biology™ book series (MIMB, volume 223)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Understanding the Function and Regulation of Tumor Suppressor Genes

    1. Front Matter
      Pages 1-1
    2. Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa-Kumagaye, Katsuyuki Tamai
      Pages 17-26
    3. Lesley J. Jardine, Carl G. Maki
      Pages 27-38
    4. Bin-Bing S. Zhou, Michael R. Mattern, Kum Kum Khanna
      Pages 39-50
    5. Shrihari Kadkol, Jeremy Juang, Tzyy-choou Wu
      Pages 51-72
    6. Takahiko Kobayashi, Ting Wang, Hua Qian, Rainer K. Brachmann
      Pages 73-86
    7. Edward C. Thornborrow, Matthew Maurer, James J. Manfredi
      Pages 87-100
    8. Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia, Narendra Wajapeyee
      Pages 101-116
    9. M. Stacey Ricci, Wafik S. El-Deiry
      Pages 117-127
    10. Sally A. Amundson, Albert J. Fornace Jr.
      Pages 141-153
    11. E. Robert McDonald III, Wafik S. El-Deiry
      Pages 173-185
    12. Ruth Hemmer, Wenyi Wei, Annie Dutriaux, John M. Sedivy
      Pages 187-206
    13. David T. Dicker, Wafik S. El-Deiry
      Pages 211-215
    14. Timothy K. MacLachlan, Wafik S. El-Deiry
      Pages 217-220
    15. Michael Dohn, Susan Nozell, Amy Willis, Xinbin Chen
      Pages 221-235
    16. Andrew M. Arsham, M. Celeste Simon
      Pages 249-270
    17. David T. Dicker, Wafik S. El-Deiry
      Pages 271-282
    18. Stephen N. Jones, Lawrence A. Donehower
      Pages 283-314
    19. Meredith Unger, Valerie M. Weaver
      Pages 315-347
    20. Raymond A. Pagliarini, Ana T. Quiñones, Tian Xu
      Pages 349-382
    21. Mark Redston
      Pages 383-401
    22. Smita Lakhotia, Kumaravel Somasundaram
      Pages 403-412
  3. Medicinal Applications of Tumor Suppessors

    1. Front Matter
      Pages 413-413
    2. Nickolas Papadopoulos
      Pages 415-423
    3. Cristina T. Lewis, Patrick M. O’Connor
      Pages 425-463
    4. Ramadevi Nimmanapalli, Kapil Bhalla
      Pages 465-483
    5. Zhong Yun, Amato J. Giaccia
      Pages 485-504
    6. Lee V. Madrid, Albert S. Baldwin Jr.
      Pages 523-532
    7. Dario C. Altieri
      Pages 533-542
    8. Eyal Gottlieb, Craig B. Thompson
      Pages 543-554
    9. Jack A. Roth, Susan F. Grammer
      Pages 577-597
    10. Michael S. O’Reilly
      Pages 599-633
  4. Back Matter
    Pages 649-657

About this book


Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics
Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.

Editors and affiliations

  • Wafik S. El-Deiry
    • 1
    • 2
    • 3
  1. 1.Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphia
  2. 2.Department of GeneticsUniversity of Pennsylvania School of MedicinePhiladelphia
  3. 3.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphia

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-987-2
  • Online ISBN 978-1-59259-329-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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Oncology & Hematology