Tumor Suppressor Genes

Volume 1: Pathways and Isolation Strategies

  • Wafik S. El-Deiry

Part of the Methods in Molecular Biology™ book series (MIMB, volume 222)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Known Tumor Suppessor Genes and Pathways

    1. Front Matter
      Pages 1-1
    2. Marco G. Paggi, Armando Felsani, Antonio Giordano
      Pages 3-19
    3. Patrice J. Morin, Ashani T. Weeraratna
      Pages 21-40
    4. Ralph Scully, Nadine Puget
      Pages 41-57
    5. William M. Grady, Sanford D. Markowitz
      Pages 59-83
    6. Anthony G. Quinn, Ervin Epstein Jr.
      Pages 85-95
    7. Arvind K. Virmani, Adi F. Gazdar
      Pages 97-115
    8. Jenny Varley
      Pages 117-129
    9. Jun-ichi Okano, Lorraine Snyder, Anil K. Rustgi
      Pages 131-145
    10. Ramon Parsons, Laura Simpson
      Pages 147-166
    11. Michael Ohh, William G. Kaelin Jr.
      Pages 167-183
    12. Kapaettu Satyamoorthy, Meenhard Herlyn
      Pages 185-195
    13. Greg H. Enders
      Pages 197-209
    14. Teresa Acosta Almeida, Nickolas Papadopoulos
      Pages 211-222
    15. Margaret E. McLaughlin, Tyler Jacks
      Pages 223-237
    16. Andrew P. Feinberg, Bryan R. G. Williams
      Pages 239-248
    17. Theodore L. DeWeese, William G. Nelson
      Pages 249-268
    18. Paul Dent, Liang Qiao, Donna Gilfor, Michael Birrer, Steven Grant, Paul B. Fisher
      Pages 269-292
  3. Identification of Tumor Suppressor Genes

    1. Front Matter
      Pages 293-293
    2. Jennifer J. Ascaño, Steven M. Powell
      Pages 295-307
    3. Keri Fair, Michelle M. Le Beau
      Pages 327-337
    4. Gavin P. Robertson, Linda Sargent, Mark A. Nelson
      Pages 339-364
    5. Bryan L. Betz, Bernard E. Weissman
      Pages 365-373
    6. Mamoun Ahram, Michael R. Emmert-Buck
      Pages 375-384
    7. James M. Bugni, Norman R. Drinkwater
      Pages 385-397
    8. Kathy Boon, Gregory J. Riggins
      Pages 463-479
  4. Back Matter
    Pages 501-504

About this book


Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.
Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.


Colon angiogenesis cell biology gene expression influence proteins regulation

Editors and affiliations

  • Wafik S. El-Deiry
    • 1
  1. 1.Departments of Medicine, Genetics, and PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphia

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-986-5
  • Online ISBN 978-1-59259-328-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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