Combinatorial Library

Methods and Protocols

  • Lisa Bellavance English

Part of the Methods in Molecular Biology™ book series (MIMB, volume 201)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Library Synthesis and Quality Control

    1. Front Matter
      Pages 1-1
    2. Fahad Al-Obeidi, John F. Okonya, Richard E. Austin, Dan R. S. Bond
      Pages 3-14
    3. Jean-Louis Aubagnac, Robert Combarieu, Christine Enjalbal, Jean Martinez
      Pages 15-22
    4. Viktor Krchňák, Andrew Burritt
      Pages 41-59
    5. Peter O. Krutzik, A. Richard Chamberlin
      Pages 77-92
    6. Brian R. Linton
      Pages 111-122
    7. Gérard Rossé, Peter Neidig, Harald Schröder
      Pages 123-139
    8. Paul Wentworth Jr., Carsten Spanka
      Pages 167-187
    9. Bing Yan, Liling Fang, Mark M. Irving, Jiang Zhao, Diana Liu, Gianine M. Figliozzi et al.
      Pages 189-200
  3. Library Purification and Screening

    1. Front Matter
      Pages 201-201
    2. Tingyu Li, Yan Wang, Louis H. Bluhm
      Pages 203-213
    3. Seema Choudhary, Janet R. Morrow
      Pages 215-225
    4. David S. Thorpe, Gérard Rossé, Helen Yeoman, Sydney Wilson, Patti Willson, Greg Harlow et al.
      Pages 239-263
  4. Computational Library Design

    1. Front Matter
      Pages 265-265
    2. Alex M. Aronov
      Pages 267-276
    3. Stefan Güssregen, Bernd Wendt, Mark Warne
      Pages 277-295
    4. John I. Manchester, David S. Hartsough
      Pages 307-323
  5. Back Matter
    Pages 369-384

About this book


By significantly increasing the number of targets available for drug discovery, the Human Genome and Proteome projects have made the use of combinatorial libraries essential to developing and optimizing drug candidate molecules more rapidly. Lisa English and a panel of expert researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. A variety of well-known computational approaches are provided to meet the information management challenge of multiple biological assays. Each readily reproducible technique includes detailed step-by-step instructions and helpful notes on troubleshooting and avoiding pitfalls.
Timely and highly practical, Combinatorial Library Methods and Protocols makes available for all drug discovery researchers all the powerful combinatorial chemistry tools that are increasing the number of candidate compounds and speeding the process of drug discovery and development today.

Editors and affiliations

  • Lisa Bellavance English
    • 1
  1. 1.BD BiosciencesSan Jose

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2002
  • Publisher Name Springer, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-980-3
  • Online ISBN 978-1-59259-285-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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