© 2000

Alzheimer's Disease

Methods and Protocols

  • Nigel M. Hooper

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 32)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. David Allsop
    Pages 1-21
  3. Nick Brindle, Peter St. George-Hyslop
    Pages 23-43
  4. Daniel M. Skovronsky, Jun Wang, Virginia M.-Y. Lee, Robert W. Doms
    Pages 79-89
  5. Matthias Staufenbiel, Paolo A. Paganetti
    Pages 91-99
  6. Kurt R. Brunden, June Kocsis-Angle, Paula Embury, Stephen L. Yates
    Pages 101-112
  7. Barbara Cordell, Asha Naidu
    Pages 139-148
  8. Jochen Walter, Christian Haass
    Pages 149-168
  9. Chen Liu, Tomasz Rozmyslowicz, Magda Stwora-Wojczyk, Boguslaw Wojczyk, Steven L. Spitalnik
    Pages 169-190
  10. S. Parvathy, Anthony J. Turner, Nigel M. Hooper
    Pages 203-215
  11. Martin Citron
    Pages 229-238
  12. Toshiharu Suzuki, Kanae Ando, Ko-ichi Iijima, Shinobu Oguchi, Shizu Takeda
    Pages 271-282
  13. Gopal Thinakaran, Andrew Doan
    Pages 283-296

About this book


With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy.
Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today‚s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge.

Editors and affiliations

  • Nigel M. Hooper
    • 1
  1. 1.University of LeedsLeedsUK

Bibliographic information

  • Book Title Alzheimer's Disease
  • Book Subtitle Methods and Protocols
  • Editors Nigel M. Hooper
  • Series Title Methods in Molecular Medicine™
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-0-89603-737-3
  • Softcover ISBN 978-1-61737-161-5
  • eBook ISBN 978-1-59259-195-4
  • Series ISSN 1543-1894
  • Series E-ISSN 1940-6037
  • Edition Number 1
  • Number of Pages XIV, 408
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurology
  • Buy this book on publisher's site
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"...this volume contains well-written chapters containing factual insights and useful clarifications. An example is David Allsop's introduction of the field through the orthodox views of the amyloid cascade hypothesis that in the exposition of others is often quite simplistic, but here is presented with complexity and wisdom deserving of serious consideration....they are provided in a format that invites the reader to undertake studies and examine the underpinnings of the subject beyond that found in the primary publications and not covered in such a practical manner in other reviews."- Journal of Molecular Neuroscience