Protein Structure, Stability, and Folding

  • Kenneth P. Murphy

Part of the Methods in Molecular Biology™ book series (MIMB, volume 168)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Kenneth P. Murphy
    Pages 1-16
  3. Beatrice M. P. Huyghues-Despointes, C. Nick Pace, S. Walter Englander, J. Martin Scholtz
    Pages 69-92
  4. Vincent J. Hilser
    Pages 93-116
  5. Trevor P. Creamer
    Pages 117-132
  6. Carl Frieden, Enoch S. Huang, Jay W. Ponder
    Pages 133-158
  7. Back Matter
    Pages 249-252

About this book


With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments.
Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.

Editors and affiliations

  • Kenneth P. Murphy
    • 1
  1. 1.University of Iowa College of MedicineIowa City

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-682-6
  • Online ISBN 978-1-59259-193-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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