Quantitative Trait Loci

Methods and Protocols

  • Nicola J. Camp
  • Angela Cox

Part of the Methods in Molecular Biology™ book series (MIMB, volume 195)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Mapping Quantitative Trait Loci in Humans

    1. Front Matter
      Pages 1-1
    2. Jennifer H. Barrett
      Pages 3-12
    3. Lyle J. Palmer, Audrey H. Schnell, John S. Witte, Robert C. Elston
      Pages 13-35
    4. Chad P. Garner
      Pages 37-60
    5. Angela J. Marlow
      Pages 61-100
    6. Mark M. Iles
      Pages 101-138
  3. Mapping Quantitative Trait Loci in Rodents

  4. Mapping Quantitative Trait Loci in Agricultural Settings

    1. Front Matter
      Pages 281-281
    2. Shizhong Xu
      Pages 283-310
    3. Joao L. Rocha, Daniel Pomp, L. Dale Van Vleck
      Pages 311-346
  5. Back Matter
    Pages 347-359

About this book


Statistical methods for the analysis of quantitative trait locus (QTL), in conjunction with genome-wide screening technologies, are today yielding exciting results in the study of human disease, experimental organisms, and agriculture. In Quantitative Trait Loci: Methods and Protocols, Drs. Nicola Camp and Angela Cox have assembled a highly experienced panel of statistical geneticists who demonstrate in a step-by-step fashion how to use this powerful methodology and associated software for the detection and fine mapping of quantitative trait loci. Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and useful variations and/or extensions to standard methods are included that ease the reader toward understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov chain Monte Carlo method for joint linkage and segregation analysis.
Up-to-date and highly practical, Quantitative Trait Loci: Methods and Protocols makes available to nonmathematical investigators a step-by-step guide to the productive use today of all the latest techniques for localizing genes involved in complex quantitative traits.

Editors and affiliations

  • Nicola J. Camp
    • 1
  • Angela Cox
    • 2
  1. 1.Genetic Epidemiology, Department of Medical InformaticsUniversity of Utah School of MedicineSalt Lake City
  2. 2.Institute for Cancer StudiesUniversity of Sheffield Medical SchoolSheffieldUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-927-8
  • Online ISBN 978-1-59259-176-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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