© 2000

Hepatocellular Carcinoma

Methods and Protocols

  • Nagy A. Habib

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 45)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Clinical Problem

    1. Front Matter
      Pages 1-34
    2. Valery Usatoff, Nagy A. Habib
      Pages 3-20
    3. Stephen M. Riordan, Roger Williams
      Pages 21-34
  3. HCC Carcinogenesis

    1. Front Matter
      Pages 35-96
    2. Satoshi Ishido, Tsunenori Fujita, Hak Hotta
      Pages 37-55
    3. Carmen Vandelli, Francesco Renzo
      Pages 71-96
  4. Molecular and Biological Characteristics

  5. HCC Gene Therapy

    1. Front Matter
      Pages 175-269
    2. Shuichi Kaneko, Taiki Tamaoki
      Pages 177-187
    3. Ragai R. Mitry, Michael D. Kelly, Jian Zhao, Satoko Negishi, Marc R. Mansour, Nagy A. Habib
      Pages 207-220

About this book


Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. The book focuses on gene therapy approaches, including the use of such vectors as lipids, adenovirus, and baculovirus, and virus detection assessment using electron microscopy. It also provides preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense compounds to growth factors, immunotherapy (remove gene), and virus-directed enzyme prodrug therapy. A perspective on future treatment of the failing liver is given, along with a clinical protocol for p53 gene therapy.
Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma.

Editors and affiliations

  • Nagy A. Habib
    • 1
  1. 1.Liver Surgery SectionImperial College School of Medicine, Hammersmith HospitalLondonUK

Bibliographic information

  • Book Title Hepatocellular Carcinoma
  • Book Subtitle Methods and Protocols
  • Editors Nagy A. Habib
  • Series Title Methods in Molecular Medicine™
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-0-89603-785-4
  • Softcover ISBN 978-1-4899-4169-5
  • eBook ISBN 978-1-59259-079-7
  • Series ISSN 1543-1894
  • Series E-ISSN 1940-6037
  • Edition Number 1
  • Number of Pages XIII, 302
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology


"...The molecular techniques are presented in a very useful format...This is a unique book with tools presented that can be directly applied to bench, translational, and clinical research. The step-by-step protocols are comprehensive and easy to understand." -Doody's Health Science Book Review Journal