Antisense Therapeutics

  • Sudhir Agrawal

Part of the Methods in Molecular Medicine book series (MIMM, volume 1)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Paul C. Zamecnik
    Pages 1-11
  3. C. Frank Bennett, Nicholas Dean, David J. Ecker, Brett P. Monia
    Pages 13-46
  4. Leonard M. Neckers, Daniel Geselowitz, Christine Chavany, Luke Whitesell, Raymond Bergan
    Pages 47-56
  5. Marina Catsicas, Astrid Osen-Sand, Julie K. Staple, Kenneth A. Jones, Guidon Ayala, Jonathan Knowles et al.
    Pages 57-85
  6. Eric Wickstrom
    Pages 87-108
  7. Anil P. Amaratunga, Kenneth S. Kosik, Peter A. Rittenhouse, Susan E. Leeman, Richard E. Fine
    Pages 109-119
  8. Michael Simons, Robert D. Rosenberg
    Pages 121-141
  9. Wolf-Bernhard Offensperger, Silke Offensperger, Hubert E. Blum
    Pages 143-158
  10. Wolfgang Brysch, Abdalla Rifai, Wolfgang Tischmeyer, Karl-Hermann Schlingensiepen
    Pages 159-182
  11. Jose R. Perez, Kimberly A. Higgins-Sochaski, Jean-Yves Maltese, Ramaswamy Narayanan
    Pages 183-199
  12. Patrick L. Iversen, Bryan L. Copple, Hemant K. Tewary, Eliel Bayever, Michael R. Bishop
    Pages 201-212
  13. Yoon S. Cho-Chung, Maria Nesterova
    Pages 213-224
  14. Bernard J. Chiasson, Murray Hong, Michele L. Hooper, John N. Armstrong, Paul R. Murphy, Harold A. Robertson
    Pages 225-245
  15. Sudhir Agrawal, Jamal Temsamani
    Pages 247-270
  16. Back Matter
    Pages 271-276

About this book


Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.

Editors and affiliations

  • Sudhir Agrawal
    • 1
  1. 1.Hybridon, Inc.Worcester

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1996
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-305-4
  • Online ISBN 978-1-59259-585-3
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site
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