In Vitro Toxicity Testing Protocols

  • Sheila O’Hare
  • Chris K. Atterwill

Part of the Methods in Molecular Biology™ book series (MIMB, volume 43)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Alternative Method of Assessing Toxicity

    1. Chris K. Atterwill
      Pages 1-9
  3. Target Organ Toxicity

    1. David J. White, Chris Seaman
      Pages 11-16
    2. Mark R. Cookson, R. McClean, Vietor W. Pentreatk
      Pages 17-23
    3. Carmel Mothersill
      Pages 25-31
    4. Stephen P. Bidey
      Pages 33-42
    5. Yrjö Collan, Veli- Matti Kosma
      Pages 43-49
    6. Paul A. Duffy
      Pages 67-74
    7. Carmel Mothersill
      Pages 75-79
    8. Glenda E. Gillies, Julia C. Buckingham
      Pages 95-107
  4. General and Topical Toxicity

    1. Richard H. Clothier
      Pages 109-118
    2. Geirid Fiskesjö
      Pages 119-127
    3. Rosa Supino
      Pages 137-149
    4. Vera Bianchi
      Pages 151-160
    5. Odile Blein-Sella, Monique Adolphe
      Pages 161-167
    6. Odile Blein-Sella, Monique Adolphe
      Pages 169-175
    7. H. M. Liebsck, Horst Spielmann
      Pages 177-187
    8. Udo Kristen, Rolf Kappler
      Pages 189-198
  5. Irritancy Testing

  6. Immunotoxicity

    1. Jennifer Hilton, Ian Kimber
      Pages 227-235
    2. Matteo Valentino
      Pages 237-244
    3. Steve Nicklin
      Pages 245-256
  7. Carcinogenesis

  8. Submammalian and Subvertebrate Models

    1. Wendy J. Davies, Stuart J. Freeman
      Pages 307-310
    2. Wendy J. Davies, Stuart J. Freeman
      Pages 311-316
    3. Wendy J. Davies, Stuart J. Freeman
      Pages 317-320
    4. Wendy J. Davies, Stuart J. Freeman
      Pages 321-326
  9. Back Matter
    Pages 327-332

About this book


In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many toxicologists have for some time been unhappy with the quantity (often a result of unnecessary duplication), the reliability, and the ethical circumstances of much animal experimentation. It is hoped that the present book, In Vitro Toxicity Testing Protocols, will play some part in enabling and encouraging the more widespread use of in vitro techniques. Since in vitro toxicity testing methodology is evolving at such a rapid rate, this book can of necessity provide only a "snapshot" of the major techniques in use at the present time. As with the other publications in Humana Press' Methods in Molecular Biology series, the aim has been to supply information on the fundamental requirements for the establishment of new techniques within working laboratories and to describe a variety of basic in vitro methodologies. Certain of the techniques detailed here could more accurately be described as ex vivo rather than truly in vitro. No apology is made for the inclusion of these techniques.

Editors and affiliations

  • Sheila O’Hare
    • 1
  • Chris K. Atterwill
    • 1
  1. 1.University of HertfordshireHatfieldUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1995
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-282-8
  • Online ISBN 978-1-59259-530-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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