Overview
Provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process
Includes supplementary material: sn.pub/extras
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Table of contents (26 chapters)
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Elements, factors and enzymes: Structure-function and mechanism
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Antivirals: Targets, mechanisms and resistance
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Front Matter
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Back Matter
Keywords
About this book
Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.
Reviews
From the reviews:
"Viruses are primarily classified by the structure of their genomes. … they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. … the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. … I recommend this title to all those interested in viral replication." (Christopher Ring, Microbiology Today, November, 2009)
Bibliographic Information
Book Title: Viral Genome Replication
Editors: Kevin D. Raney, Matthias Gotte, Craig E. Cameron
DOI: https://doi.org/10.1007/b135974
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2009
Hardcover ISBN: 978-0-387-89425-6Published: 21 July 2009
Softcover ISBN: 978-1-4899-8468-5Published: 03 December 2014
eBook ISBN: 978-0-387-89456-0Published: 28 May 2009
Edition Number: 1
Number of Pages: XVIII, 636
Topics: Virology, Microbiology, Immunology, Cell Biology, Biochemistry, general, Human Genetics
Industry Sectors: Biotechnology, Pharma