The Biology and Pathology of Innate Immunity Mechanisms

1. Innate Immunity in the Compromised Host

   1. Clinical Significance of Functional Aberrations in Macrophage and NK Cells, in Type-1 Cytokines and in Lectin-Binding Molecules

      • Zeev T. Handzel

      Pages 227-235

   2. Klebsiella Infections in the Immunocompromised Host

      • Hany Sahly, Rainer Podschun, Uwe Ullmann

      Pages 237-249

2. Innate Immunity Components in Cancer

   1. Macrophage-Recognized Molecules of Apoptotic Cells are Expressed at Higher Levels in AKR Lymphoma of Aged as Compared to Young Mice

      • O. Itzhaki, E. Skutelsky, T. Kaptzan, A. Siegal, M. Michowitz, J. Sinai et al.

      Pages 251-262

   2. Sensitivity to Macrophages Decreases with Tumor Progression in the AKR Lymphoma

      • T. Kaptzan, E. Skutelsky, M. Michowitz, A. Siegal, O. Itzhaki, S. Hoenig et al.

      Pages 263-275

   3. Opposing Effects of IL-1α and IL-1β on Malignancy Patterns

      • Ron N. Apte, Tatyana Dvorkin, Xiaoping Song, Eyal Fima, Yakov Krelin, Alon Yulevitch et al.

      Pages 277-288

   4. Abstracts

      Pages 289-322

3. Back Matter

   Pages 323-328

   PDF

In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.

• antigen
• antimicrobial
• antimicrobial peptides
• bacteria
• bacterial infection
• infection
• infections
• infectious diseases

• Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

  Yona Keisari, Itzhak Ofek

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