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Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS

  • Santokh Gill
  • Olga Pulido

Table of contents

  1. Front Matter
    Pages i-xv
  2. General Concepts

  3. Specific Target Tissues, Organs, and Systems

    1. Front Matter
      Pages 97-97
    2. Victoria P. Connaughton
      Pages 99-127
    3. Albertino Bigiani
      Pages 129-145
    4. Tania F. Gendron, Paul Morley
      Pages 147-168
    5. Daniela Jezova, Marek Schwendt
      Pages 169-178
    6. Li Hsueh Tsai, Jang-yen Wu
      Pages 179-190
    7. Gary J. Spencer, Ian S. Hitchcock, Paul G. Genever
      Pages 197-209
    8. Marianna Storto, Maria Pia Vairetti, Francesc X. Sureda, Barbara Riozzi, Valeria Bruno, Ferdinando Nicoletti
      Pages 211-217
    9. Helga S. Haas, Konrad Schauenstein
      Pages 219-232
  4. Non-Mammalian Organisms

    1. Front Matter
      Pages 243-243
    2. Joanna C. Chiu, Eric D. Brenner, Rob DeSalle, Nora M. Barboza, Gloria M. Coruzzi
      Pages 245-255
  5. Back Matter
    Pages 257-270

About this book

Introduction

Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza­ tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.

Keywords

Calcium biology brain cancer molecular biology neurons time

Editors and affiliations

  • Santokh Gill
    • 1
  • Olga Pulido
    • 1
  1. 1.Toxicology Research DivisionHPFB, Health CanadaOttawaCanada

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