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Phospholipid Metabolism in Apoptosis

  • Peter J. Quinn
  • Valerian E. Kagan

Part of the Subcellular Biochemistry book series (SCBI, volume 36)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Volker Lehmann, Vladimir Shatrov
    Pages 1-17
  3. Yoshihiro Shidoji, Sadaaki Komura, Nobuko Ohishi, Kunio Yagi
    Pages 19-37
  4. Peter J. Quinn
    Pages 39-60
  5. Kazuo Emoto, Masato Umeda
    Pages 61-77
  6. Y. Y. Tyurina, V. A. Tyurin, S. X. Liu, C. A. Smith, A. A. Shvedova, N. F. Schor et al.
    Pages 79-96
  7. C. Patrick Burns, Eric E. Kelley, Brett A. Wagner, Garry R. Buettner
    Pages 97-121
  8. Hervé Benoist, Robert Salvayre, Anne Nègre-Salvayre
    Pages 123-150
  9. Karin Öllinger, Katarina Kågedal
    Pages 151-170
  10. Cristiano Ferlini, Raffaele D’ Amelio, Giovanni Scambia
    Pages 171-186
  11. Samer El Bawab, Cungui Mao, Lina M. Obeid, Yasuf A. Hannun
    Pages 187-205
  12. Erich Gulbins, Richard Kolesnick
    Pages 229-244
  13. Jean-Pierre Jaffrézou, Guy Laurent, Thierry Levade
    Pages 269-284
  14. Alessandra Rufini, Roberto Testi
    Pages 285-308
  15. Back Matter
    Pages 335-340

About this book

Introduction

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.

Keywords

Lipid Oxidation biosynthesis metabolism molecular mechanisms regulation

Editors and affiliations

  • Peter J. Quinn
    • 1
  • Valerian E. Kagan
    • 2
  1. 1.Kings College LondonLondonUK
  2. 2.University of PittsburghPittsburgh

Bibliographic information

  • DOI https://doi.org/10.1007/b105359
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-46782-0
  • Online ISBN 978-0-306-47931-1
  • Series Print ISSN 0306-0225
  • Buy this book on publisher's site
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