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Molecular Targeting and Signal Transduction

  • Book
  • © 2004

Overview

Editors:
  1. Rakesh Kumar

    1. M. D. Anderson Cancer Center, The University of Texas, Houston, USA

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  • Describes the key pathways and factors involved in this process.
  • Distinguished leaders in the field discuss the therapeutic compounds and strategies being developed for the treatment of malignant disease

Part of the book series: Cancer Treatment and Research (CTAR, volume 119)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
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  2. Biology of the Epidermal Growth Factor Receptor Family

    • Christopher J. Barnes, Rakesh Kumar
    Pages 1-13

  3. Integrin Signaling in Cancer

    • Hira Lal Goel, Lucia R. Languino
    Pages 15-31

  4. Regulators of Vascular Endothelial Growth Factor Expression in Cancer

    • Oliver Stoeltzing, Lee M. Ellis
    Pages 33-58

  5. Integrin-Linked Kinase (ILK) in Combination Molecular Targeting

    • Lincoln A Edwards, Jennifer A Shabbits, Marcel Bally, Shoukat Dedhar
    Pages 59-75

  6. P21-Activated Kinase 1: An Emerging Therapeutic Target

    • Ratna K. Vadlamudi, Rakesh Kumar
    Pages 77-88

  7. Basis and Importance of SRC as a Target in Cancer

    • Victor A. Levin
    Pages 89-119

  8. Therapeutic Targeting of the Receptor Tyrosine Kinase Met

    • Martin Sattler, Patrick C. Ma, Ravi Salgia
    Pages 121-138

  9. Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer

    • Shishir Shishodia, Bharat B. Aggarwal
    Pages 139-173

  10. The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics

    • Shulin Wang, Wafik S. El-Deiry
    Pages 175-181

  11. Runx Protein Signaling in Human Cancers

    • Ian Anglin, Antonio Passaniti
    Pages 189-215

  12. Signal Transduction Mediated by Cyclin D1: from Mitogens to Cell Proliferation: A Molecular Target with Therapeutic Potential

    • Chenguan Wang, Zhiping Li, Maofu Fu, Toula Bouras, Richard G. Pestell
    Pages 217-237

  13. Signal Transduction Pathways in BCR-ABL Transformed Cells

    • Ralph Arlinghaus, Tong Sun
    Pages 239-270

  14. Estrogen Receptors and Anti-Estrogen Therapies

    • Lakjaya Buluwela, Demetra Constantinidou, Joanna Pike, Simak Ali
    Pages 271-292

  15. Targeting Endothelin Axis in Cancer

    • Anna Bagnato, Pier Giorgio Natali
    Pages 293-314

  16. km23: A Novel TGFβ Signaling Target Altered in Ovarian Cancer

    • Wei Ding, Kathleen M. Mulder
    Pages 315-327

  17. Back Matter

    Pages 329-331
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Keywords

About this book

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development.

This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Editors and Affiliations

  • M. D. Anderson Cancer Center, The University of Texas, Houston, USA

    Rakesh Kumar

Bibliographic Information

  • Book Title: Molecular Targeting and Signal Transduction

  • Editors: Rakesh Kumar

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/b105352

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-4020-7822-4Published: 30 April 2004

  • Softcover ISBN: 978-1-4757-7968-4Published: 24 April 2013

  • eBook ISBN: 978-1-4020-7847-7Published: 18 April 2006

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: VIII, 331

  • Topics: Oncology, Cancer Research

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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