# Foundations of Pharmacokinetics

• Aldo Rescigno
Book

1. Front Matter
Pages i-xvi
2. Pages 1-3
3. Pages 5-15
4. Pages 17-26
5. Pages 27-35
6. Pages 37-50
7. Pages 51-59
8. Pages 61-68
9. Pages 69-82
10. Pages 83-93
11. Pages 95-111
12. Pages 113-125
13. Pages 127-134
14. Pages 135-141
15. Pages 143-147
16. Pages 149-159
17. Pages 161-170
18. Pages 171-177
19. Pages 179-180
20. Back Matter
Pages 181-228

### Introduction

This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. It was not my intention to write a popular book; what distinguishes this one from many others on the same subject is its large use of algebra and calculus. For this I make no apologies; in fact a serious study of pharmacokinetics without the help of mathematics is, in my opinion, impossible. The exact definition of many pharmacokinetic quantities, even the most common, and the correct use of many equations, even the most simple, requires the constant use of mathematical language. On the other hand I have made a considerable effort to use only elementary algebra and elementary calculus, as commonly taught in most introductory university courses. For the few exceptions, when less common mathematical concepts were needed, I have supplied the necessary explanations in four appendices. The first three chapters are a general introduction to the scientific method. Chapters 4 to 12 show different specific methods to deal with pharmacokinetic pr- lems. There is considerable overlap among those chapters; this is intentional and its p- pose is to convince the reader that every problem can be solved in more than one way, including ways that were not mentioned in this book and that intelligent readers can find for their own pleasure. Chapters 13 to 17 show how different parameters of importance in pharmacokinetics can be exactly defined and measured.

### Keywords

bioequivalence kinetics pharmacokinetics research

#### Authors and affiliations

• Aldo Rescigno
• 1
1. 1.University of MinnesotaMinneapolis

### Bibliographic information

• DOI https://doi.org/10.1007/b105300
• Copyright Information Kluwer Academic Publishers 2003
• Publisher Name Springer, Boston, MA
• eBook Packages
• Print ISBN 978-0-306-47704-1
• Online ISBN 978-0-306-47924-3