Dipeptidyl Aminopeptidases in Health and Disease

  • Nathan Back
  • Irun R. Cohen
  • David Kritchevsky
  • Abel Lajtha
  • Rodolfo Paoletti

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 524)

Table of contents

  1. Front Matter
    Pages i-xxxii
  2. Structure and Function of Dipeptidyl Aminopeptidases

    1. Ingrid De Meester, Anne-Marie Lambeir, Paul Proost, Simon Scharpé
      Pages 3-17
    2. Anne-Marie Lambeir, Dean Rea, Vilmos Fülö, Yumi Kumagai, Koen Augustyns, Ingrid De Meester et al.
      Pages 29-35
    3. Katerina Ajami, Catherine A. Abbott, Vanessa Gysbers, Thilo Kähne, Geoffrey W. McCaughan, Mark D. Gorrell
      Pages 49-55
    4. Kerstin Kühn-Wache, Torsten Hoffmann, Susanne Manhart, W. Brandt, Hans-Ulrich Demuth
      Pages 57-63
    5. Carmen Mrestani-Klaus, Wolfgang Brandt, Jürgen Faust, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge et al.
      Pages 65-68
    6. Angela Stöckel-Maschek, Beate Stiebitz, Jürgen Faust, Ilona Born, Thilo Kähne, Mark D. Gorrell et al.
      Pages 69-72
    7. Q. Thai Dinh, Christian Peiser, Axel Fischer, David A. Groneberg
      Pages 73-76
  3. DPP IV-Like Enzymes

    1. Tong Chen, Katerina Ajami, Geoffrey W. McCaughan, Mark D. Gorrell, Catherine A. Abbott
      Pages 79-86
    2. G. Ghersi, H. Dong, L.A. Goldstein, Y. Yeh, L. Hakkinen, H.S. Larjava et al.
      Pages 87-94
    3. Radek Malík, Petr Bušek, Vladislav Mareš, Jan Ševčík, Zdeněk Kleibl, Aleksi Šedo
      Pages 95-102
    4. Joachim W. Baer, Bernd Gerhartz, Torsten Hoffmann, Fred Rosche, Hans-Ulrich Demuth
      Pages 103-108
    5. Daniel Friedrich, Kerstin Kühn-Wache, Torsten Hoffmann, Hans-Ulrich Demuth
      Pages 109-113
    6. Joerg Stork, Torsten Hoffmann, Hans-Ulrich Demuth
      Pages 115-119
  4. Immune Mechanisms and Immune Disorders

    1. Uwe Lendeckel, Marco Arndt, Alicja Bukowska, Janine Tadje, Carmen Wolke, Thilo Kähne et al.
      Pages 123-131
    2. Stephan Korom, Ingrid De Meester, A. Belyaev, Georg Schmidbauer, Konrad Schwemmle
      Pages 133-143
    3. Juan Lojo, Francisco J. Salgado, Montserrat Nogueira, Oscar J. Cordero
      Pages 145-153
    4. Jens Rüter, Hans-Ulrich Demuth, Petra C. Arck, Torsten Hofmann, Burghard F. Klapp, Martin Hildebrandt
      Pages 155-163

About this book


Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.

Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:

- Structure and function of dipeptidyl aminopeptidases,
- DPP IV-like proteins,
- Immune mechanisms and immune disorders,
- Cancer and angiogenesis,
- Diabetes and metabolism,
- Therapeutic implications.


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Editors and affiliations

  • Nathan Back
    • 2
  • Irun R. Cohen
    • 3
  • David Kritchevsky
    • 4
  • Abel Lajtha
    • 5
  • Rodolfo Paoletti
    • 1
  1. 1.University of MilanItaly
  2. 2.State University of New York at BuffaloUSA
  3. 3.The Weizmann Institute of ScienceIsrael
  4. 4.Wistar InstituteUSA
  5. 5.N.S. Kline Institute for Psychiatric ResearchUSA

Bibliographic information

  • DOI https://doi.org/10.1007/b105297
  • Copyright Information Kluwer Academic Publishers 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-47717-1
  • Online ISBN 978-0-306-47920-5
  • Series Print ISSN 0065-2598
  • About this book
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