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Genome Integrity

  • Editors
  • Dirk-Henner Lankenau

Part of the Genome Dynamics and Stability book series (GENOME, volume 1)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Replication

    1. Front Matter
      Pages 1-2
    2. Heinz Peter Nasheuer, Helmut Pospiech, Juhani Syväoja
      Pages 27-68
    3. Kristijan Ramadan, Giovanni Maga, Ulrich Hübscher
      Pages 69-102
  3. Replicative Double-Strand Break Repair

  4. Facets of Double-Strand Break Repair

    1. Front Matter
      Pages 199-200
    2. Petra Pfeiffer, Steffi Kuhfittig-Kulle, Wolfgang Goedecke
      Pages 219-242
    3. Susanne Andrea Gatz, Lisa Wiesmüller
      Pages 243-266
  5. DNA Repair and Pleiotropic Interactions

    1. Front Matter
      Pages 285-286
    2. Grigory L. Dianov, Sarah L. Allinson
      Pages 287-314
    3. Birgitte B. Olsen, Karsten Niefind, Olaf-Georg Issinger
      Pages 315-342
    4. Kent Søe, Anja Rockstroh, Frank Grosse
      Pages 343-362
  6. Radiation and other Genotoxic Stress

    1. Front Matter
      Pages 381-382
    2. Markus Christmann, Gerhard Fritz, Bernd Kaina
      Pages 383-398
    3. Elza T. Sakamoto-Hojo, Stephano S. Mello, Carmen L. Bassi, Igor M. Merchi, Patricia O. Carminati, Ana L. Fachin et al.
      Pages 423-452
  7. Back Matter
    Pages 479-496

About this book

Introduction

Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.

Keywords

Chromosom DNA DNA Repair Genetics Genome Dynamics Genome Integrity Replication Viruses base chromosome evolution genes microorganisms

Bibliographic information

  • DOI https://doi.org/10.1007/b104871
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-37528-9
  • Online ISBN 978-3-540-37531-9
  • Series Print ISSN 1861-3373
  • Buy this book on publisher's site
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