Systems and Synthetic Immunology

1. Front Matter

   Pages i-vii

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2. Vaccine Design, Nanoparticle Vaccines and Biomaterial Applications

   • Pragya Misra, Shailza Singh

   Pages 1-52

3. Systems Immunology Approach in Understanding the Association of Allergy and Cancer

   • Sreyashi Majumdar, Sudipto Saha

   Pages 53-72

4. Genome Engineering Tools in Immunotherapy

   • Rashmi Dahiya, Taj Mohammad, Md. Imtaiyaz Hassan

   Pages 73-102

5. Bioinformatics Tools for Epitope Prediction

   • Mohini Jaiswal, Shafaque Zahra, Shailesh Kumar

   Pages 103-124

6. A Chronological Journey of Breg Subsets: Implications in Health and Disease

   • Hamid Y. Dar, Lekha Rani, Leena Sapra, Zaffar Azam, Niti Shokeen, Asha Bhardwaj et al.

   Pages 125-152

7. T-Cell Activation and Differentiation: Role of Signaling and Metabolic Cross-Talk

   • Rupa Bhowmick, Piyali Ganguli, Ram Rup Sarkar

   Pages 153-182

8. Innate Immune Signaling in Cardiac Homeostasis and Cardiac Injuries

   • Asma Naseem, Hashim Ali

   Pages 183-200

9. Role of Regulatory T Lymphocytes in Health and Disease

   • Niti Shokeen, Chaman Saini, Leena Sapra, Zaffar Azam, Asha Bhardwaj, Ayaan Ahmad et al.

   Pages 201-243

10. Implication of Synthetic Biology in Biotherapeutic Engineering

    • Taj Mohammad, Rashmi Dahiya, Md. Imtaiyaz Hassan

    Pages 245-253

11. Cytokines in Cancer Immunotherapy

    • Raki Sudan

    Pages 255-269

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology.


The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

• Systems Immunology
• Synthetic immunology
• Genomic engineering
• Biosensors
• Cytokines
• Systems Biology
• genetic engineering

• National Centre for Cell Science, Pune, India

  Shailza Singh

Dr. Shailza Singh is a scientist at the Bioinformatics and High Performance Computing Facility, NCCS, Pune, India. Her research chiefly focuses on the systems and synthetic biology of infectious diseases such as leishmaniasis. In this regard, her group is working to integrate the action of regulatory circuits, cross-talk between pathways, and non-linear kinetics of biochemical processes through mathematical modeling. Dr. Singh has been honored with the DBT RGYI, DST Young Scientist and INSA Bilateral Exchange Programme awards, and was selected by the DBT for a SAKURA EXCHANGE Programme in Science in the field of Artificial Intelligence and Machine learning to Tokyo in 2018. She serves as a reviewer for prestigious international grants such as the RCUK; for national grants from the DBT, DST and CSIR; and for several prominent international journals, e.g. Parasite and Vectors, PLOS One, BMC Infectious Disease, BMC Research Notes, Oncotarget, and the International Journal of Cancer.

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