Editors:
- Focuses on protein allostery in drug discovery
- Draws together the study of protein structure/function and the study of allostery
- Contributed by experts in this field
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1163)
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Table of contents (15 chapters)
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Front Matter
About this book
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Editors and Affiliations
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Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
Jian Zhang
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Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA, Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ruth Nussinov
About the editors
Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA
Bibliographic Information
Book Title: Protein Allostery in Drug Discovery
Editors: Jian Zhang, Ruth Nussinov
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-8719-7
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-8718-0Published: 20 November 2019
Softcover ISBN: 978-981-13-8721-0Published: 20 November 2020
eBook ISBN: 978-981-13-8719-7Published: 09 November 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XII, 384
Number of Illustrations: 21 b/w illustrations, 82 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Protein Science, Protein Structure, Biomedical Engineering/Biotechnology
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Pharma