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  • Book
  • © 2019

Antimicrobial Peptides

Basics for Clinical Application

  • Presents the latest findings on antimicrobial peptides

  • Elucidates their mechanisms of antimicrobial action

  • Examines AMP activities beyond antimicrobial action

  • Discusses the progress made, and obstacles to, their clinical application

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1117)

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  • ISBN: 978-981-13-3588-4
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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
  2. Introduction

    1. Front Matter

      Pages 1-1
  3. Mechanisms of Antimicrobial Action

    1. Front Matter

      Pages 7-7
    2. Membrane Permeabilization Mechanisms

      • Katsumi Matsuzaki
      Pages 9-16
    3. Anionic Lipid Clustering Model

      • Richard M. Epand
      Pages 65-71
  4. Other Activities of AMPs

    1. Front Matter

      Pages 91-91
    2. Synthetic Anti-lipopolysaccharide Peptides (SALPs) as Effective Inhibitors of Pathogen-Associated Molecular Patterns (PAMPs)

      • Wilmar Correa, Lena Heinbockel, Guillermo Martinez-de-Tejada, Susana Sánchez, Patrick Garidel, Tobias Schürholz et al.
      Pages 111-129
    3. Anticancer Activities of Natural and Synthetic Peptides

      • A. L. Hilchie, D. W. Hoskin, M. R. Power Coombs
      Pages 131-147
    4. Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects

      • Anne M. van der Does, Pieter S. Hiemstra, Neeloffer Mookherjee
      Pages 149-171
  5. Towards Clinical Applications

    1. Front Matter

      Pages 173-173
    2. Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37

      • Guangshun Wang, Jayaram Lakshmaiah Narayana, Biswajit Mishra, Yingxia Zhang, Fangyu Wang, Chunfeng Wang et al.
      Pages 215-240
    3. AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis

      • Hawraa Shahrour, Raquel Ferrer-Espada, Israa Dandache, Sergio Bárcena-Varela, Susana Sánchez-Gómez, Ali Chokr et al.
      Pages 257-279
    4. Clinical Application of AMPs

      • Fabíola Costa, Cátia Teixeira, Paula Gomes, M. Cristina L. Martins
      Pages 281-298

About this book

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

Keywords

  • Mechanism of action
  • Antisepsis agent
  • Anticancer agent
  • Clinical application
  • Peptide translocation

Editors and Affiliations

  • Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Japan

    Katsumi Matsuzaki

About the editor

Katsumi Matsuzaki is a Professor at the Graduate School of Pharmaceutical Sciences, Kyoto University, where he also completed his PhD in Biophysical Chemistry. Dr. Matsuzaki has authored more than 100 publications, which have been cited more than 10000 times. In addition to serving as an editor for Biochimica et Biophysica Acta-Biomembranes, Journal of Peptide Science, and European Biophysics Journal, he is a member of the Biophysical Society (USA), The Pharmaceutical Society Japan, The Japanese Peptide Society, and The Biophysical Society of Japan. He was awarded The Japanese Peptide Society Award for Young Scientists, The Pharmaceutical Society Japan Award for Young Scientists, and the Erwin von Bälz Prize. His primary research interest is in membrane biophysics, including peptide–membrane interactions and in-cell biophysics.

Bibliographic Information

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-981-13-3588-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book USD 199.99
Price excludes VAT (USA)