Overview
- Describes the general aspects of muscle atrophy
- Overviews molecular mechanisms of muscle atrophy
- Provides diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1088)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (29 chapters)
-
Front Matter
-
Overview
-
Front Matter
-
-
Basic Aspects of Muscle Atrophy
-
Front Matter
-
-
Molecular Mechanisms of Muscle Atrophy
-
Front Matter
-
-
Muscle Atrophy in Diseases and Aging
-
Front Matter
-
Keywords
About this book
The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.
Editors and Affiliations
About the editor
Dr. Junjie Xiao is Principal Investigator and Professor at Regeneration and Ageing Lab in Shanghai University, Shanghai, China.
Bibliographic Information
Book Title: Muscle Atrophy
Editors: Junjie Xiao
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-1435-3
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-13-1434-6Published: 20 November 2018
eBook ISBN: 978-981-13-1435-3Published: 02 November 2018
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XV, 624
Number of Illustrations: 24 b/w illustrations, 52 illustrations in colour
Topics: Molecular Medicine, Cell Biology, Human Physiology
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Health & Hospitals, Pharma