Introduction in Synthetic Biology

About Modeling, Computation, and Circuit Design

  • Mario Andrea Marchisio

Part of the Learning Materials in Biosciences book series (LMB)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Mario Andrea Marchisio
    Pages 1-5
  3. Mario Andrea Marchisio
    Pages 7-28
  4. Mario Andrea Marchisio
    Pages 29-38
  5. Mario Andrea Marchisio
    Pages 39-52
  6. Mario Andrea Marchisio
    Pages 53-65
  7. Mario Andrea Marchisio
    Pages 67-83
  8. Mario Andrea Marchisio
    Pages 85-90
  9. Mario Andrea Marchisio
    Pages 91-107
  10. Mario Andrea Marchisio
    Pages 109-129
  11. Mario Andrea Marchisio
    Pages 131-148
  12. Mario Andrea Marchisio
    Pages 149-158
  13. Mario Andrea Marchisio
    Pages 159-183
  14. Back Matter
    Pages 185-187

About this book


The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.


Synthetic Biology Mathematical Models Synthetic Gene Circuits Structural Motifs Parameter Analysis

Authors and affiliations

  • Mario Andrea Marchisio
    • 1
  1. 1.School of Life Science and TechnologyHarbin Institute of TechnologyHarbinChina

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-10-8751-6
  • Online ISBN 978-981-10-8752-3
  • Series Print ISSN 2509-6125
  • Series Online ISSN 2509-6133
  • Buy this book on publisher's site
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