Basic, Genomic, and Clinical

  • Shigeru Saito

Part of the Comprehensive Gynecology and Obstetrics book series (CGO)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Risk Factors for Preeclampsia

    1. Front Matter
      Pages 1-1
    2. Arihiro Shiozaki, Shigeru Saito
      Pages 3-25
  3. Genetic Background in Preeclampsia

    1. Front Matter
      Pages 27-27
    2. Junichi Sugawara, Yuji Oe, Maiko Wagata
      Pages 29-43
  4. Pathological Findings in Preeclampsia

    1. Front Matter
      Pages 45-45
  5. Pathophysiology of Preeclampsia

    1. Front Matter
      Pages 63-63
    2. Shigeru Saito, Tomoko Shima, Akitoshi Nakashima
      Pages 65-84
    3. Katsuhiko Naruse
      Pages 113-124
    4. Akitoshi Nakashima, Aiko Aoki, Tae Kusabiraki, Tomoko Shima, Osamu Yoshino, Shi-Bin Cheng et al.
      Pages 125-140
    5. Keiichi Kumasawa
      Pages 141-155
    6. Anne Cathrine Staff, Christopher W. G. Redman
      Pages 157-172
  6. Prediction of Preeclampsia

    1. Front Matter
      Pages 173-173
    2. Holger Stepan, Janine Hoffmann
      Pages 175-198
    3. Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara, Toshiyuki Takeshita, Shigeru Saito
      Pages 209-224
  7. Therapy

    1. Front Matter
      Pages 225-225
    2. Suzanne D. Burke, S. Ananth Karumanchi
      Pages 227-237
    3. Guillermina Girardi
      Pages 239-251
  8. The Risk of Cardiovascular Events in Preeclamptic Cases

    1. Front Matter
      Pages 271-271
    2. Franziska Pettit, George Mangos, Mark A. Brown
      Pages 273-290

About this book


This volume is an excellent guide that comprehensively illustrates hypertensive disorders of pregnancy, especially preeclampsia, in both the basic and clinical aspects.

Preeclampsia is a pregnancy-specific multi-organ disorder and a leading cause of maternal and neonatal mortality. The pathophysiology of pregnancy-specific disorders was long unknown, but recently many new findings have been reported from the point of view of pathophysiology. Furthermore, this complication of pregnancy, especially preeclampsia, is a potent risk factor for chronic conditions such as cardiovascular disease, diabetes mellitus, kidney disease, and hypertension.

The book is composed of seven parts including genetic background, pathology,  pathophysiology, and the latest prediction and treatment of preeclampsia. Specific basic topics such as immunological maladaptation, placental adenosine signaling, and new prediction markers are also expounded by experts. Thus it benefits not only obstetricians, pediatricians, nephrologists, diabetologists, and cardiologists, but also immunologists, endocrinologists, geneticists, pathologists, biologists, and molecular biologists who are interested in the treatment of hypertension in pregnancy.


Obesity Glucose intolerance Insulin resistance Lipokine sFlt-1/PlGF

Editors and affiliations

  • Shigeru Saito
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of ToyamaToyamaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-5890-5
  • Online ISBN 978-981-10-5891-2
  • Series Print ISSN 2364-1932
  • Series Online ISSN 2364-219X
  • Buy this book on publisher's site
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