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Mechanism of Functional Expression of the Molecular Machines

  • Book
  • © 2016

Overview

Authors:
  1. Masahiro Kinoshita

    1. Institute of Advanced Energy, Kyoto University, Kyoto, Japan

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  • Provides many illustrations to facilitate understanding
  • Gives explanations in words rather than by mathematical equations
  • Offers detailed descriptions so that readers can understand without referring to the references
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)

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Table of contents (4 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • Masahiro Kinoshita
    Pages 1-3

  3. Importance of Translational, Configurational Entropy of Water

    • Masahiro Kinoshita
    Pages 5-20

  4. Molecular Machines

    • Masahiro Kinoshita
    Pages 21-61

  5. Concluding Remarks: Mechanism of Functional Expression Common in the Molecular Machines

    • Masahiro Kinoshita
    Pages 63-70
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Keywords

About this book

This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.

Authors and Affiliations

  • Institute of Advanced Energy, Kyoto University, Kyoto, Japan

    Masahiro Kinoshita

About the author

Prof. Dr. Masahiro KinoshitaInstitute of Advanced Energy Kyoto University

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