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Stress Response Pathways in Cancer

From Molecular Targets to Novel Therapeutics

  • Book
  • © 2015

Overview

Editors:
  1. Georg T. Wondrak

    1. Dept. of Pharmacology and Toxicology, Univ. of Arizona, College of Pharm. & The Univ. of Arizona Cancer Ctr., Tucson, USA

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  • The book covers very recent research that promises to revolutionize cancer-directed chemotherapeutic interventions
  • The book provides a unique translational coverage between molecular cancer biology and cancer-directed therapeutic development
  • The book provides state-of-the-art coverage written by recognized experts from five continents
  • Includes supplementary material: sn.pub/extras

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Introduction to Cell Stress Responses in Cancer: The Big Picture

    • Georg T. Wondrak
    Pages 1-5

  3. DNA Repair Dysregulation in Cancer: From Molecular Mechanisms to Synthetic Lethal Opportunities

    • Jac A. Nickoloff
    Pages 7-28

  4. Cell Cycle Checkpoint and DNA Damage Response Defects as Anticancer Targets: From Molecular Mechanisms to Therapeutic Opportunities

    • Loredana Spoerri, Zay Yar Oo, Jill E. Larsen, Nikolas K. Haass, Brian Gabrielli, Sandra Pavey
    Pages 29-49

  5. p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities

    • Luciana E. Giono, M. Fátima Ladelfa, Martín Monte
    Pages 51-73

  6. Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities

    • Núria Sima, Laia Bosch-Presegué, Alejandro Vaquero
    Pages 75-106

  7. MicroRNA Regulated Stress Responses in Cancer

    • Haoran Li, Shaan Gupta, Burton B. Yang
    Pages 107-126

  8. Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities

    • Sandra Muñoz-Galvan, Amancio Carnero
    Pages 127-155

  9. Pro-senescence Therapy for Cancer: Time for the Clinic

    • Madhuri Kalathur, Diletta Di Mitri, Andrea Alimonti
    Pages 157-182

  10. Integrating Proteotoxic Stress Response Pathways for Induction of Cell Death in Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities

    • Kristopher S. Raghavan, Robert Clarke, Ayesha N. Shajahan-Haq
    Pages 183-202

  11. The Hsp70 Family of Heat Shock Proteins in Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities

    • Anna Budina-Kolomets, Subhasree Basu, Lili Belcastro, Maureen E. Murphy
    Pages 203-224

  12. The Ubiquitin-Proteasome System (UPS) as a Cancer Drug Target: Emerging Mechanisms and Therapeutics

    • Lydia Mata-Cantero, Sofía Lobato-Gil, Fabienne Aillet, Valérie Lang, Manuel S. Rodriguez
    Pages 225-264

  13. Endoplasmic Reticulum Stress in Multiple Myeloma: From Molecular Mechanisms to Therapeutic Opportunities

    • Bei Liu, Zihai Li
    Pages 265-284

  14. Melanomagenic Gene Alterations Viewed from a Redox Perspective: Molecular Mechanisms and Therapeutic Opportunities

    • Georg T. Wondrak
    Pages 285-309

  15. Targeting Hypoxic Adaptations of Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities

    • Ceen-Ming Tang, Jun Yu
    Pages 311-329

  16. Targeting Glycolytic Adaptations of Cancer Cells: From Molecular Mechanisms to Therapeutic Opportunities

    • Shanmugasundaram Ganapathy-Kanniappan
    Pages 331-344

  17. At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Cancer Drug Target

    • Varda Shoshan-Barmatz, Anna Shteinfer, Danya Ben-Hail, Tasleem Arif, Dario Mizrachi
    Pages 345-373

  18. Inflammatory Dysregulation and Cancer: From Molecular Mechanisms to Therapeutic Opportunities

    • Colin W. Steele, Nigel B. Jamieson, C. Ross Carter
    Pages 375-395

  19. Cell-Nonautonomous ER Stress-Mediated Dysregulation of Immunity by Cancer Cells

    • Jeffrey J. Rodvold, Navin R. Mahadevan, Maurizio Zanetti
    Pages 397-429

  20. Back Matter

    Pages 431-446
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Keywords

About this book

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.

Editors and Affiliations

  • Dept. of Pharmacology and Toxicology, Univ. of Arizona, College of Pharm. & The Univ. of Arizona Cancer Ctr., Tucson, USA

    Georg T. Wondrak

Bibliographic Information

  • Book Title: Stress Response Pathways in Cancer

  • Book Subtitle: From Molecular Targets to Novel Therapeutics

  • Editors: Georg T. Wondrak

  • DOI: https://doi.org/10.1007/978-94-017-9421-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2015

  • Hardcover ISBN: 978-94-017-9420-6Published: 21 November 2014

  • Softcover ISBN: 978-94-024-0385-5Published: 10 September 2016

  • eBook ISBN: 978-94-017-9421-3Published: 07 November 2014

  • Edition Number: 1

  • Number of Pages: XII, 446

  • Number of Illustrations: 4 b/w illustrations, 52 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Oncology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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