Mutant p53 and MDM2 in Cancer

  • Swati Palit Deb
  • Sumitra Deb

Part of the Subcellular Biochemistry book series (SCBI, volume 85)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Diana Merino, David Malkin
    Pages 1-16
  3. Kazushi Inoue, Elizabeth A. Fry
    Pages 17-40
  4. Javier E. Girardini, Dawid Walerych, Giannino Del Sal
    Pages 41-70
  5. Catherine Vaughan, Isabella Pearsall, Andrew Yeudall, Swati Palit Deb, Sumitra Deb
    Pages 71-90
  6. Raffaela Santoro, Sabrina Strano, Giovanni Blandino
    Pages 91-103
  7. W. A. Yeudall
    Pages 105-117
  8. Hector Viadiu, Gilberto Fronza, Alberto Inga
    Pages 119-132
  9. Leila Tchelebi, Hani Ashamalla, Paul R. Graves
    Pages 133-159
  10. Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt et al.
    Pages 161-186
  11. Rebecca A. Frum, Steven R. Grossman
    Pages 187-197
  12. E. Douglas Robertson, Kostyantyn Semenchenko, Bohdan Wasylyk
    Pages 199-214
  13. Swati Palit Deb, Shilpa Singh, Sumitra Deb
    Pages 215-234
  14. Stephen Bohlman, James J. Manfredi
    Pages 235-246
  15. Melissa Rosso, Danielle E. Okoro, Jill Bargonetti
    Pages 247-261
  16. Steven J. Berberich
    Pages 263-280
  17. Qi Zhang, Shelya X. Zeng, Hua Lu
    Pages 281-319
  18. Venkat Sundar Gadepalli, Swati Palit Deb, Sumitra Deb, Raj R. Rao
    Pages 359-370

About this book

Introduction

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis.

This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

Keywords

Cancer MDM2 Mutation Oncogenesis p53

Editors and affiliations

  • Swati Palit Deb
    • 1
  • Sumitra Deb
    • 2
  1. 1.Department of Biochemistry and Molecular Biology, and the Massey Cancer CenterVirginia Commonwealth UniversityRichmondUSA
  2. 2.Department of Biochemistry and Molecular Biology, and the Massey Cancer CenterVirginia Commonwealth UniversityRichmondUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-9211-0
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-9210-3
  • Online ISBN 978-94-017-9211-0
  • Series Print ISSN 0306-0225
  • About this book
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