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Aminoacyl-tRNA Synthetases in Biology and Medicine

  • Book
  • © 2014

Overview

Editors:
  1. Sunghoon Kim

    1. Department of Molecular Medicine and Biopharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Korea, Republic of (South Korea)

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  • Will attract broad readership from basic life science to biotechnology and medical community
  • Describes how aminoacyl-tRNA synthetases give insight into the emergence and evolution of life
  • Shows how the function of a gene can be diversified at protein level
  • Describes how a central metabolism such as protein synthesis is coordinated with other cellular processes
  • Covers ARS-related pathologies and novel activities, which provide new understanding of human diseases and therapeutic opportunities
  • Written by leading experts in the field

Part of the book series: Topics in Current Chemistry (TOPCURRCHEM, volume 344)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases

    • John J. Perona, Ita Gruic-Sovulj
    Pages 1-41

  3. Emergence and Evolution

    • Tammy J. Bullwinkle, Michael Ibba
    Pages 43-87

  4. Architecture and Metamorphosis

    • Min Guo, Xiang-Lei Yang
    Pages 89-118

  5. Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases

    • Jong Hyun Kim, Jung Min Han, Sunghoon Kim
    Pages 119-144

  6. Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication

    • Sung Hwa Son, Min Chul Park, Sunghoon Kim
    Pages 145-166

  7. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases

    • Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox
    Pages 167-187

  8. Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications

    • Sagi Tshori, Ehud Razin, Hovav Nechushtan
    Pages 189-206

  9. Association of Aminoacyl-tRNA Synthetases with Cancer

    • Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim
    Pages 207-245

  10. Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases

    • Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler
    Pages 247-292

  11. Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development

    • Varun Dewan, John Reader, Karin-Musier Forsyth
    Pages 293-329

  12. Flexizymes, Their Evolutionary History and Diverse Utilities

    • Toby Passioura, Hiroaki Suga
    Pages 331-345

  13. Back Matter

    Pages 347-350
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Keywords

About this book

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.

Editors and Affiliations

  • Department of Molecular Medicine and Biopharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Korea, Republic of (South Korea)

    Sunghoon Kim

About the editor

1983–1986 Researcher, Genetic Eng. Center, KAIST, Korea
1991–1994 Post-doc, MIT, USA
1993–1994 Senior Scientist, Cubist Pharmaceuticals, USA
1994-2001 Associate Professor, Sung Kyun Kwan University, Korea
2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ.
1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University
2008- Director, Information Center of Bio-pharmacological Network
2008- Director, Integrated Bioscience and Biotechnology Institute

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