Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

  • Domenico Ribatti

Table of contents

  1. Front Matter
    Pages i-xi
  2. Domenico Ribatti
    Pages 1-5
  3. Domenico Ribatti
    Pages 7-33
  4. Domenico Ribatti
    Pages 35-47
  5. Domenico Ribatti
    Pages 49-55
  6. Domenico Ribatti
    Pages 57-84
  7. Domenico Ribatti
    Pages 85-87
  8. Back Matter
    Pages 89-114

About this book


It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.


angiogenesis antiangiogenesis hematological malignancies tumor growth tumor microenvironment

Authors and affiliations

  • Domenico Ribatti
    • 1
  1. 1.Basic Medical Sciences, Neurosciences and Sensory OrgansUniversity of Bari Medical SchoolBariItaly

Bibliographic information

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