The Role of Aging in Atherosclerosis

The sequestration hypothesis

  • Richard E. Tracy

Table of contents

  1. Front Matter
    Pages i-x
  2. Richard E. Tracy
    Pages 1-10
  3. Richard E. Tracy
    Pages 131-140

About this book

Introduction

The cover of this book summarizes the central features of the sequestration hypothesis: Commonplace appearances seen in human coronary artery, fat stained in paraffin seetions by a new technique explained in Chapter Eleven, are arranged to suggest pathways of evolution toward atheroma. The hypothesis formulated and defended in the pages ofthis book is this: Fibroplasia progresses upward in column "a" from "la" to "3a" as a characteristic feature of aging. This starts sooner and progresses faster in men than in wornen. Numbers ofSMC's remain essentially constant so that fibroplasia per SMC steadily increases. The rise upward conveys an increasing propensity to sequester atherogenic lipids, causing transition rightward into column "b". Sequestered extracellular lipid then attracts fatty streak elements, especially foam cells and lyrnphocytes, to propel the arterial site rightward into column "c". Frame "lc" corresponds to the AHA Lesions Committee classification type IIb, the progression resistant fatty streak arising directly without prior lipid sequestration; this can progress to atheroma, but slowly after much delay, although extreme provocation can accelerate the process. Such progression is rightward toward atherorna with thin cap, not upward toward fibroplastic thickening. Frame "2c" corresponds to the AHA classification, type Ha, progression prone fatty streaks. These readily evolve into atheroma, again by horizontal progression.

Keywords

artery atherosclerosis diabetes histology hypertension treatment

Authors and affiliations

  • Richard E. Tracy
    • 1
  1. 1.Department of PathologyLouisiana State University Health Science CenterNew OrleansUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-0263-8
  • Copyright Information Springer Science+Business Media B.V. 2003
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-6265-9
  • Online ISBN 978-94-017-0263-8
  • About this book
Industry Sectors
Biotechnology
Pharma