Advanced Instrumentation, Data Interpretation, and Control of Biotechnological Processes

1. Front Matter

   Pages i-xvii

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2. Hardware Sensors

   1. Front Matter

      Pages 1-1

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   2. Flow Injection Analysis for On-line Monitoring of a Wastewater Treatment Plant

      • S. Isaacs, H. Søeberg

      Pages 3-40

   3. On-line Measurement of Viable Biomass

      • A. J. C. Spierings

      Pages 41-66

   4. Membrane Inlet Mass Spectrometry for the Characterization and Monitoring of Biotechnological Processes

      • F. R. Lauritsen

      Pages 67-103

   5. Flow Cytometry

      • P. Breeuwer

      Pages 105-120

   6. Microcalorimetric Characterization of Bacterial Inocula

      • H. Vandenhove

      Pages 121-158

3. Model based Control

   1. Front Matter

      Pages 159-159

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   2. On-line Data Acquisition

      • P. A. Willems, J. P. Ottoy

      Pages 161-190

   3. Data Processing for System Identification

      • P. Van Overschee

      Pages 191-209

   4. Error Diagnosis and Data Reconciliation Using Linear Conservation Relations

      • C. Hellinga, B. Romein, K. Ch. A. M. Luyben, J. J. Heijnen

      Pages 211-244

   5. General Concepts of Bioprocess Modeling

      • G. C. Vansteenkiste

      Pages 245-250

   6. Bioprocess Model Identification

      • P. A. Vanrolleghem, D. Dochain

      Pages 251-318

   7. Optimal Control of Fed-Batch Fermentation Processes

      • J. F. Van Impe

      Pages 319-346

   8. Monitoring and Adaptive Control of Bioprocesses

      • D. Dochain, M. Perrier

      Pages 347-400

   9. Optimal Adaptive Control of Fed-Batch Fermentation Processes

      • J. F. Van Impe, G. Bastin

      Pages 401-435

   10. Predictive Control in Biotechnology using Fuzzy and Neural Models

       • H. Te Braake, R. Babuska, E. Van Can, C. Hellinga

       Pages 437-464

This book is the outgrowth of the COMETT II Course on Advanced Instru­ mentation, Data Interpretation, and Control of Biotechnological Processes organized by the Katholieke Universiteit Leuven and the Universiteit Gent, and held at Gent, Belgium, October 1994. The editors of the present volume were very fortunate to find all invited speakers prepared to write state-of-the-art expositions based on their lec­ tures. Special thanks are due to all of them. The result is an account of recent advances in instrumentation, data interpretation, and model based op­ timization and control of bioprocesses. For anyone interested in this emerg­ ing field, this text is of value and provides comprehensive reviews as well as new and important trends and directions for the future, motivated and illustrated by a wealth of applications. The typesetting of all this material represented a tremendous amount of work. I am most grateful to my wife, Myriam Uyttendaele, and to Kurt Gheys, who did most of the proof-reading. Their efforts have increased a lot the uniformity in style and presentation of the different manuscripts. Many thanks also to the co-editors, for their continued support. Kluwer Academic Publishers is gratefully acknowledged for publishing this book, thus contributing to the transfer of the latest research results into large scale industrial applications.

• Analysis
• Fermentation
• algorithm
• biotechnology
• control engineering
• fuzzy
• mathematical modeling
• model
• modeling
• optimization
• systems theory
• air pollution and air quality

• Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Leuven, Belgium

  Jan F. M. Impe, Dirk M. Iserentant

• Department of Applied Mathematics, Biometrics and Process Control, Universiteit Gent, Gent, Belgium

  Peter A. Vanrolleghem

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