Structure-Based Drug Design

Experimental and Computational Approaches

  • Penelope W. Codding

Part of the NATO ASI Series book series (NSSE, volume 352)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Douglas C. Rohrer
    Pages 65-76
  3. N. Borkakoti, F. K. Winkler, D. H. Williams, A. D’Arcy, K. Bottomley, D. Bradshaw et al.
    Pages 77-85
  4. Flemming Steen Jørgensen, Inge Thøger Christensen, Anja Rabijns
    Pages 95-101
  5. Ettore Benedetti, Rosa Iacovino, Michele Saviano
    Pages 103-112
  6. Jason C. Cole, Jos P. M. Lommerse, R. Scott Rowland, Robin Taylor, Frank H. Allen
    Pages 113-124
  7. Richard Pauptit, Simon Weston, Siân Rowsell, Dean Derbyshire, Alec Tucker
    Pages 125-139
  8. Ross D. King, Michael J. E. Sternberg, Stephen H. Muggleton, Ashwin Srinivasan
    Pages 151-162
  9. Peter D. J. Grootenhuis, Constant A. A. van Boeckel
    Pages 163-173
  10. W. L. Duax, D. Ghosh, V. Pletnev
    Pages 175-194
  11. Douglas C. Rohrer, Jordi Mestres
    Pages 211-222
  12. Benjamin J. Burke, Xinjun Hou, Thomas F. Hendrickson
    Pages 239-247
  13. Richard Pauptit, Simon Weston, Alex Breeze, Dean Derbyshire, Alec Tucker, Neil Hales et al.
    Pages 255-270
  14. Back Matter
    Pages 285-289

About this book


Structure-Based Drug Design brings together scientists working on different aspects of the subject, demonstrating the necessary collaboration and interdisciplinary approach to this complex area. The focus is on X-ray crystallographic and computational approaches. The general aspects of these approaches are introduced in the first six articles. The remaining articles provide examples of the application of X-ray crystallography, molecular modelling, molecular dynamics, QSAR, database analysis, and homology modelling. The papers cover a wealth of interesting problems in the design of new and enhanced pharmaceuticals.


Amino acid base drug design molecular modelling pharmaceuticals protein receptor

Editors and affiliations

  • Penelope W. Codding
    • 1
  1. 1.Department of ChemistryUniversity of VictoriaVictoriaCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1998
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-5078-6
  • Online ISBN 978-94-015-9028-0
  • Series Print ISSN 0168-132X
  • Buy this book on publisher's site
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